急性乙型肝炎中的e抗原
e antigen in acute hepatitis B.
作者信息
Norkrans G, Magnius L, Iwarson S
出版信息
Br Med J. 1976 Mar 27;1(6012):740-2. doi: 10.1136/bmj.1.6012.740.
Abstract
To examine the association between e antigen and hepatitis-B surface antigen (HBs Ag) we studied 90 inpatients with acute viral hepatitis type B. e Antigen was present in 24 of the patients; these patients had detectable levels of HBs Ag for significantly longer than the 66 with no e antigen in their serum. The HBs Ag subtypes D (adw) and Y (ayw) were similarly distributed among patients with e antigen and among those without, and no differences in the results of biochemical liver function tests were observed between the two groups during the acute phase of illness. Three of the five patients who developed clinical and histological signs of chronic liver disease were positive for e antigen, a finding which supports the hypothesis that e antigen has a prognostic value in hepatitis B.
摘要
为了研究e抗原与乙型肝炎表面抗原（HBs Ag）之间的关联，我们对90例急性乙型病毒性肝炎住院患者进行了研究。24例患者存在e抗原；这些患者血清中可检测到HBs Ag的时间明显长于另外66例血清中无e抗原的患者。e抗原阳性患者和e抗原阴性患者中HBs Ag亚型D（adw）和Y（ayw）的分布相似，且在疾病急性期两组之间未观察到肝功能生化检查结果的差异。出现慢性肝病临床和组织学体征的5例患者中有3例e抗原呈阳性，这一发现支持了e抗原在乙型肝炎中具有预后价值的假说。
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本文引用的文献
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N Engl J Med. 1973 Mar 8;288(10):484-7. doi: 10.1056/NEJM197303082881002.
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[Ultrastructural study of "Australia" antigen. 1. Morphological diversity of Australia antigen].["“澳大利亚”抗原的超微结构研究。1. 澳大利亚抗原的形态多样性]
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Lancet. 1974 Oct 19;2(7886):913-5. doi: 10.1016/s0140-6736(74)91127-1.
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