乙酰胆碱受体抗体与正常、去神经支配及重症肌无力患者的人体肌肉受体相互作用的差异。
Differences in the interaction of acetylcholine receptor antibodies with receptor from normal, denervated and myasthenic human muscle.
作者信息
Lefvert A K
出版信息
J Neurol Neurosurg Psychiatry. 1982 Jan;45(1):70-3. doi: 10.1136/jnnp.45.1.70.
Abstract
The interaction of acetylcholine receptor antibodies with different kinds of human skeletal muscle receptor was investigated. The reaction of most receptor antibodies was strongest with receptor from a patient with myasthenia gravis and with receptor from denervated muscle. Results obtained with these receptors were well correlated. The binding of most receptor antibodies to receptor from functionally normal muscle was much weaker and also qualitatively different. In a few patients with moderate and severe clinical symptoms the existence of acetylcholine receptor antibodies was revealed only by their reaction with receptor from myasthenic muscle. One patient had a clone of receptor antibodies reacting exclusively with receptor from her own muscle.
摘要
研究了乙酰胆碱受体抗体与不同种类人骨骼肌受体的相互作用。大多数受体抗体与重症肌无力患者的受体以及去神经肌肉的受体反应最强。用这些受体获得的结果相关性良好。大多数受体抗体与功能正常肌肉的受体的结合要弱得多，而且在性质上也有所不同。在少数有中度和重度临床症状的患者中，仅通过它们与重症肌无力肌肉的受体反应才发现乙酰胆碱受体抗体的存在。一名患者有一群受体抗体，仅与她自己肌肉的受体发生反应。
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