Loewi G, Temple A, Nind A P, Axelrad M
Immunology. 1969 Jan;16(1):99-106.
Anti-guinea-pig and anti-mouse macrophage sera were prepared by immunizing rabbits with peritoneal cells which had been purified by short culture. Such sera caused agglutination and lysis of macrophages , as well as Cr release, which showed some specificity for macrophages when compared with lymph node lymphocytes. Intravenous administration of anti-macrophage serum to guinea-pigs caused impairment of carbon clearance. Mice given anti-macrophage serum and immunized with sheep erythrocytes showed a normal plaque formation response. In guinea-pigs, local injection of anti-macrophage serum followed by immunization gave rise to a decreased delayed hypersensitivity response, but anti-lymphocyte serum, and to some extent anti-kidney serum, also caused a diminution.
用经短期培养纯化的腹腔细胞免疫家兔，制备了抗豚鼠和抗小鼠巨噬细胞血清。这类血清可引起巨噬细胞的凝集和裂解，以及铬释放，与淋巴结淋巴细胞相比，对巨噬细胞表现出一定的特异性。给豚鼠静脉注射抗巨噬细胞血清会导致碳清除功能受损。给予抗巨噬细胞血清并用绵羊红细胞免疫的小鼠表现出正常的空斑形成反应。在豚鼠中，局部注射抗巨噬细胞血清后再进行免疫会导致迟发型超敏反应降低，但抗淋巴细胞血清以及在一定程度上抗肾血清也会使其减弱。
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