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[骨关节炎膝关节滑液的酶学研究(作者译)]

[Enzyme studies of synovial fluid from osteoarthritis knee joints (author's transl)].

作者信息

Weseloh G, Lenz L, Weidlich W

出版信息

Arch Orthop Unfallchir. 1977 Jun 26;88(2):217-23. doi: 10.1007/BF00415101.

DOI:10.1007/BF00415101
PMID:577690
Abstract

In 40 patients who were operated on for meniscopathy, accompanied by more or less severe arthroses of the knee joints, the total activity of LDH-T and of the LDH-H isoenzyms could be evaluated. The data show that severe arthroses without any synovitic reactions as well as cases with inactive chronic synovitis showed small total activities of LDH, whereas cases with clinical and macroscopic-anatomically active synovitis (including the so-called activated arthroses) showed a great total activity of LDH. Furthermore the dominance of LDH-H isoenzyms has been found to indicate an aerobic situation of the metabolism.

摘要

在40例因半月板病变接受手术治疗且伴有不同程度膝关节关节炎的患者中,可评估乳酸脱氢酶总活性(LDH-T)及乳酸脱氢酶同工酶(LDH-H)。数据表明,无任何滑膜炎反应的严重关节炎以及非活动性慢性滑膜炎病例的LDH总活性较低,而具有临床及大体解剖学上活动性滑膜炎的病例(包括所谓的活动性关节炎)的LDH总活性较高。此外,已发现LDH-H同工酶占优势表明代谢处于有氧状态。

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1
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本文引用的文献

1
[Lactic dehydrogenase activity in human articular fluids of the knee].[人膝关节液中的乳酸脱氢酶活性]
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Lactic dehydrogenase isozymes and their distribution in normal tissues and plasma and in disease states.乳酸脱氢酶同工酶及其在正常组织、血浆和疾病状态下的分布。
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Isozymes of lactice dehydrogenase; their alterations in arthritic synovial fluid and sera.乳酸脱氢酶同工酶;它们在关节炎滑液和血清中的变化。
J Clin Invest. 1962 Nov;41(11):2012-9. doi: 10.1172/JCI104659.
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Significance of the heterogeneity of lactic dehydrogenase activity in human tissues.人体组织中乳酸脱氢酶活性异质性的意义。
Ann N Y Acad Sci. 1961 Nov 2;94:877-89. doi: 10.1111/j.1749-6632.1961.tb35581.x.
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Isozymes of lactic dehydrogenase in human tissues.人体组织中的乳酸脱氢酶同工酶
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[Enzymes of synovial fluid and its physiopathological importance].
Enzymologia. 1966 Feb 28;30(2):135-46.