Peters J M, Murphy R L, Ferris B G
Br J Ind Med. 1969 Apr;26(2):115-20. doi: 10.1136/oem.26.2.115.
115-120. Thirty-four workers exposed to toluene diisocyanate during production of polyurethane foam were examined with a respiratory questionnaire and tests of ventilatory capacity. The tests of pulmonary function were conducted on Monday morning and afternoon and on Tuesday morning and afternoon. Twenty-eight of these 34 workers had been examined with the same tests six months earlier. On Monday a mean change in the one-second forced expiratory volume (F.E.V.) of –0·16 l. occurred that did not return to the baseline value (Monday a.m.) on Tuesday morning. A statistically significant decrease in all the measurements of ventilatory capacity except the forced vital capacity occurred over the six months in the 28 workers. The F.E.V. fell an average of 0·14 l. and flow rates at 75%, 50%, 25%, and 10% of vital capacity also decreased significantly. There was a highly significant correlation coefficient (r = 0·72) between one-day changes in F.E.V. (measured six months earlier) and six-month changes in F.E.V.. Workers with respiratory symptoms (cough and/or phlegm) demonstrated greater falls in F.E.V. than did asymptomatic workers. All air concentrations of toluene diisocyanate measured during this study were below the threshold limit value (0·02 p.p.m.).
115 - 120。对34名在聚氨酯泡沫生产过程中接触甲苯二异氰酸酯的工人进行了呼吸问卷调查和通气能力测试。肺功能测试在周一上午、下午以及周二上午、下午进行。这34名工人中有28名在六个月前接受过相同测试。周一，一秒用力呼气量（F.E.V.）平均下降了0.16升，到周二上午仍未恢复到基线值（周一上午）。在这28名工人中，除用力肺活量外，所有通气能力测量值在六个月内均出现了具有统计学意义的下降。F.E.V.平均下降了0.14升，肺活量75%、50%、25%和10%时的流速也显著下降。F.E.V.一天内的变化（六个月前测量）与F.E.V.六个月内的变化之间存在高度显著的相关系数（r = 0.72）。有呼吸道症状（咳嗽和/或咳痰）的工人F.E.V.下降幅度比无症状工人更大。本研究期间测量的所有甲苯二异氰酸酯空气浓度均低于阈限值（0.02 ppm）。
