Tanser A R, Bourke M P, Blandford A G
Thorax. 1973 Sep;28(5):596-600. doi: 10.1136/thx.28.5.596.
, , 596-600. We investigated 57 employees of a factory where diphenyl-methane di-isocyanate (MDI) was used to prepare the materials for making rigid polyurethane foam. Four employees had developed hypersensitivity to MDI. Two had severe, and one moderate asthma, while the fourth had symptoms resembling the delayed hypersensitivity type of reaction. Ten other employees had experienced unpleasant, mainly respiratory, irritant effects from MDI vapour. A past history of bronchitis or of allergy was found more commonly in those with symptoms from MDI than in those without symptoms. It is not known if MDI causes permanent damage to the respiratory tract. The most severely affected cases in the present series had normal spirometric values after recovery, and no persisting symptoms. MDI is safer than other isocyanates used in industry but may cause both major and minor illness. It should be handled with the same precautions as those used with the more toxic compounds.
我们调查了一家使用二苯基甲烷二异氰酸酯（MDI）制备硬质聚氨酯泡沫材料的工厂的57名员工。四名员工对MDI产生了过敏反应。两人患有严重哮喘，一人患有中度哮喘，而第四名员工的症状类似于迟发性过敏反应类型。另外十名员工曾经历过MDI蒸气引起的不愉快的主要是呼吸道的刺激作用。有支气管炎或过敏病史的情况在有MDI症状的员工中比在无症状的员工中更常见。尚不清楚MDI是否会对呼吸道造成永久性损害。本系列中受影响最严重的病例康复后肺功能测定值正常，且无持续症状。MDI比工业中使用的其他异氰酸酯更安全，但可能导致严重和轻微疾病。应与处理毒性更强的化合物一样采取相同的预防措施来处理它。 （页码：596 - 600）
