Schindler K, Kraus C
Arch Otorhinolaryngol. 1977 Dec 20;218(1-2):61-6.
Lipids can be found sporadically in the maxillary sinus especially in connection with chronic sinusitis. Thus, the occurence of cholesterol is known for decades. Nevertheless most of the lipids in the excretions of maxillary sinus are unknown or less investigated still today. It may be that there is a lack of simple analytical methods. The intention of this paper is to demonstrate early results with TLC-separation and determination of lipids in the maxillary sinus excretions during sinusitis. The samples were collected from patients of the HNO-Klinik Würzburg in connection with a therapeutic rinsing of the sinus. The effluent was concentrated and then separated into three fractions by ultracentrifugation: 1. The sediment, consisting of cells and some other undefined organic material. 2. A supernatant clear solution, containing inorganic material, proteins, amino-acids, lipids... 3. Sporadically a very thin layer on the surface of the clear solution. Since fraction 3, which contains lipids too, could not be found each time, our attention was directed on the lipids of the clear solution, where most of these substances are attached to proteins. As well as in the sediment we found in the clear solution cholesterol, free fatty acids, triglycerides and very seldom cholesterol-esters. The concentration of cholesterol is nearly the same as that of free fatty acids. The frequency of occurrence of lipids is considerable which prevents us until now to correlate the lipid-content to some features of diagnosis, prognosis and therapy.
脂质偶尔会在上颌窦中被发现，尤其是与慢性鼻窦炎相关的情况下。因此，胆固醇的存在已为人所知数十年。然而，时至今日，上颌窦分泌物中的大多数脂质仍不为人知或研究较少。可能是缺乏简单的分析方法。本文旨在展示在鼻窦炎期间用上薄层色谱法分离和测定上颌窦分泌物中脂质的早期结果。样本取自维尔茨堡耳鼻喉科诊所接受鼻窦治疗性冲洗的患者。流出物被浓缩，然后通过超速离心分离成三个部分：1. 沉淀物，由细胞和一些其他未定义的有机物质组成。2. 上清液澄清溶液，含有无机物质、蛋白质、氨基酸、脂质……3. 偶尔在澄清溶液表面有一层非常薄的层。由于每次都找不到也含有脂质的第3部分，我们的注意力集中在上清液中的脂质上，其中大多数这些物质与蛋白质结合。与沉淀物一样，我们在上清液中发现了胆固醇、游离脂肪酸、甘油三酯，很少发现胆固醇酯。胆固醇的浓度与游离脂肪酸的浓度几乎相同。脂质出现的频率相当高，这使得我们至今无法将脂质含量与某些诊断、预后和治疗特征相关联。
