Vogel H H, Sebes J I
Gan. 1977 Oct;68(5):627-34.
Examinations were made on the carcinogenic effects of a chemical compound, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and a physical carcinogen, whole-body irradiation with fission neutrons, on the gastrointestinal tract of male albino Sprague-Dawley rats. The carcinogens were used singly and together in order to investigate their possible synergistic effects on the induction of adenocarcinomas of the stomach and small intestine. Of the 13 animals treated with the chemical, MNNG, and living more than 9 months, 9 showed gross tumors (5 gastric and 4 duodenal), confirming the high incidence of gastrointestinal carcinomas induced by MNNG in the rat. There were no gastrointestinal tumors found after neutron exposure. When the 2 carcinogens were combined, no additivity or synergism occurred. After neutron irradiation, a dental syndrome with loss of incisor teeth was observed. The effect of neutron irradiation on subgingival pathology of the teeth is being investigated.
对一种化合物N-甲基-N'-硝基-N-亚硝基胍（MNNG）和一种物理致癌物——裂变中子全身照射，对白化雄性斯普拉格-道利大鼠胃肠道的致癌作用进行了研究。单独及联合使用这些致癌物，以研究它们对胃和小肠腺癌诱导可能产生的协同作用。在13只接受化学物质MNNG处理且存活超过9个月的动物中，9只出现肉眼可见肿瘤（5例胃癌和4例十二指肠癌），证实MNNG在大鼠中诱发胃肠道癌的发生率很高。中子照射后未发现胃肠道肿瘤。当两种致癌物联合使用时，未出现相加或协同作用。中子照射后，观察到一种伴有门齿脱落的牙综合征。正在研究中子照射对牙齿龈下病理学的影响。
