Ammon H V, Thomas P J, Phillips S F
Gut. 1977 Oct;18(10):805-13. doi: 10.1136/gut.18.10.805.
Perfusion studies were performed in healthy volunteers to test the hypothesis that net fluid secretion induced by fatty acids is accompanied by parallel reduction in solute transport. Ricinoleic acid provoked a marked net secretion of fluid and concomitantly inhibited the absorption of all solutes tested; these included glucose, xylose, L-leucine, L-lysine, Folic acid, and 2-mono-olein. Oleic acid also reduced net fluid and solute transport, but was less potent in reducing solute absorption than was ricinoleic acid. When fluid secretion was induced osmotically with mannitol, glucose and xylose absorption was not affected. The mechanism for this generalised effect of fatty acids on solute absorption is uncertain, possibly nonspecific, and might be related to mucosal damage and altered mucosal permeability induced by these agents.
在健康志愿者中进行灌注研究，以检验脂肪酸诱导的净液体分泌伴随着溶质转运平行减少这一假设。蓖麻油酸引发了明显的液体净分泌，并同时抑制了所有测试溶质的吸收；这些溶质包括葡萄糖、木糖、L-亮氨酸、L-赖氨酸、叶酸和甘油单油酸酯。油酸也减少了液体和溶质的净转运，但在减少溶质吸收方面比蓖麻油酸的作用弱。当用甘露醇以渗透方式诱导液体分泌时，葡萄糖和木糖的吸收不受影响。脂肪酸对溶质吸收的这种普遍作用机制尚不确定，可能是非特异性的，并且可能与这些物质引起的黏膜损伤和黏膜通透性改变有关。
