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脾脏和胸腺的成对外植体在体外引发抗体合成。

Antibody synthesis initiated in vitro by paired explants of spleen and thymus.

作者信息

Saunders G C, King D W

出版信息

Science. 1966 Mar 18;151(3716):1390-1. doi: 10.1126/science.151.3716.1390.

DOI:10.1126/science.151.3716.1390
PMID:5909787
Abstract

Primary in vitro synthesis of antibody has been achieved with a mouse spleen-thymus organ culture system 54 hours after it was incubated for 18 hours with coliphage R17.

摘要

在用噬菌体R17培养18小时后，通过小鼠脾-胸腺器官培养系统在54小时内实现了抗体的初次体外合成。

相似文献

1
Antibody synthesis initiated in vitro by paired explants of spleen and thymus.脾脏和胸腺的成对外植体在体外引发抗体合成。
Science. 1966 Mar 18;151(3716):1390-1. doi: 10.1126/science.151.3716.1390.
2
In vitro studies on radiation lymphoid recovery of mouse spleen.小鼠脾脏辐射后淋巴细胞恢复的体外研究。
J Exp Med. 1966 Jan 1;123(1):25-32. doi: 10.1084/jem.123.1.25.
3
A study of the role of the thymus and spleen in the formation of antibodies in the rabbit.胸腺和脾脏在兔子抗体形成中的作用研究。
J Immunol. 1948 Jan;58(1):27-32.
4
[Antibody formation processes in the regenerated spleen of intact and thymectomized mice].[完整和胸腺切除小鼠再生脾脏中的抗体形成过程]
Biull Eksp Biol Med. 1971 Dec;72(12):52-4.
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Sites of biosynthesis of immunoglobulins in guinea-pigs immunized with bacteriophage phi-X174.用噬菌体φ-X174免疫的豚鼠中免疫球蛋白的生物合成位点。
Immunology. 1967 Dec;13(6):613-22.
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Influence of the spleen and thymus on immune responses in ageing mice.脾脏和胸腺对衰老小鼠免疫反应的影响。
Clin Exp Immunol. 1967 Jan;2(1):109-20.
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Effect of thymectomy in adult mice on immunological responsiveness.成年小鼠胸腺切除对免疫反应性的影响。
Nature. 1965 Dec 25;208(5017):1337-8. doi: 10.1038/2081337a0.
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Potentiation of lymph node antibody synthesis by normal thymus in vitro.正常胸腺在体外增强淋巴结抗体合成。
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Antibody formation in vitro by haemopoietic organs after subcutaneous and intravenous immunization.皮下和静脉免疫后造血器官在体外的抗体形成
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Studies on antibody induction in vitro. I. The nature of the primary response to soluble T2 antigens by rabbit spleen cells.体外抗体诱导的研究。I. 兔脾细胞对可溶性T2抗原的初次应答的性质。
J Immunol. 1973 Mar;110(3):811-9.

引用本文的文献

1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Time of appearance and distribution of cells capable of secondary immune response following primary immunization.初次免疫后能够产生二次免疫应答的细胞出现的时间及分布情况。
Immunology. 1967 Jun;12(6):675-87.
3
Primary antibody response in organ cultures.器官培养中的初次抗体反应。
J Exp Med. 1966 Nov 1;124(5):1001-16. doi: 10.1084/jem.124.5.1001.
4
Immune responses in vitro. I. Cellular requirements for the immune response by nonprimed and primed spleen cells in vitro.体外免疫反应。I. 体外非致敏和致敏脾细胞免疫反应的细胞需求。
J Exp Med. 1969 Aug 1;130(2):345-64. doi: 10.1084/jem.130.2.345.
5
Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters.体外初次免疫应答中的细胞相互作用：特定细胞簇的需求。
J Exp Med. 1969 Feb 1;129(2):351-62. doi: 10.1084/jem.129.2.351.
6
Maturation of hemolysin-producing cell clones. I. The kinetics of the induction period of an in vitro hemolysin response to erythrocyte antigen.产生溶血素的细胞克隆的成熟。I. 体外对红细胞抗原的溶血素反应诱导期的动力学。
J Exp Med. 1969 Sep 1;130(3):543-56. doi: 10.1084/jem.130.3.543.
7
Primary antibody response in vitro in peritoneal cells.腹膜细胞体外的初次抗体反应。
J Exp Med. 1967 May 1;125(5):873-92. doi: 10.1084/jem.125.5.873.
8
Potentiation of lymph node antibody synthesis by normal thymus in vitro.正常胸腺在体外增强淋巴结抗体合成。
Immunology. 1968 Feb;14(2):235-45.
9
Identification of immunocompetent cells in tissue culture.组织培养中免疫活性细胞的鉴定。
Am J Pathol. 1968 Jan;52(1):141-54.