青少年牙周炎中中性粒细胞趋化性缺陷。
Defective neutrophil chemotaxis in juvenile periodontitis.
作者信息
Clark R A, Page R C, Wilde G
出版信息
Infect Immun. 1977 Dec;18(3):694-700. doi: 10.1128/iai.18.3.694-700.1977.
Abstract
Neutrophil chemotaxis was evaluated in nine patients with juvenile periodontitis, with normal subjects and patients with the adult form of periodontitis as controls. Defective chemotactic responses were observed in neutrophils from seven of nine juvenile patients, and a reduced level of complement-derived chemotactic activity was demonstrated in serum from four patients. These determinations were normal in all the patients with adult periodontitis. Serum from five of the juvenile patients contained a heat-stable, non-dialyzable factor that markedly inhibited the chemotaxis of normal neutrophils. Thus the characteristic tissue destruction seen in juvenile periodontitis may be, at least in part, a consequence of a failure of host defense mechanisms.
摘要
对9例青少年牙周炎患者的中性粒细胞趋化性进行了评估，以正常受试者和成人牙周炎患者作为对照。在9例青少年患者中的7例患者的中性粒细胞中观察到趋化反应缺陷，并且在4例患者的血清中证实补体衍生的趋化活性水平降低。所有成人牙周炎患者的这些测定结果均正常。5例青少年患者的血清中含有一种热稳定、不可透析的因子，该因子可显著抑制正常中性粒细胞的趋化性。因此，青少年牙周炎中所见的特征性组织破坏可能至少部分是宿主防御机制失效的结果。
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