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磷脂霉素,磷酸糖脂类抗生素的一个新成员。I. 产生菌的分类及磷脂霉素的发酵与分离

Pholipomycin, a new member of phosphoglycolipid antibiotics. I. Taxonomy of producing organism and fermentation and isolation of pholipomycin.

作者信息

Arai M, Torikata A, Enokita R, Fukatsu H, Nakayama R, Yoshida K

出版信息

J Antibiot (Tokyo). 1977 Dec;30(12):1049-54. doi: 10.7164/antibiotics.30.1049.

Abstract

Pholipomycin is a new member of the phosphoglycolipid family of antibiotics. Taxonomic studies of the producing organism revealed that it has morphologically characteristic aerial mycelia in which two to three spores are borne usually on short and clavate side branches. The species name, Streptomyces lividoclavatus, has been proposed. Pholipomycin is produced mainly in the solid residue of the fermentation culture broth and is isolated by methanol extraction of the mycelial cake followed by purification on ion-exchange resin and silica gel chromatography.

摘要

磷脂霉素是磷酸糖脂类抗生素家族的新成员。对产生该抗生素的生物体进行的分类学研究表明,它具有形态特征性的气生菌丝体,通常在短棒状侧枝上着生两到三个孢子。已提出该物种名为淡紫棒链霉菌。磷脂霉素主要在发酵培养液的固体残渣中产生,通过对菌丝饼进行甲醇萃取,然后在离子交换树脂和硅胶柱色谱上进行纯化来分离。

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