小鼠17号染色体上的肝脏特异性溶酶体酸性磷酸酶缺乏症（Apl）。
Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse chromosome 17.
作者信息
Womack J E, Eicher E M
出版信息
Mol Gen Genet. 1977 Oct 24;155(3):315-7. doi: 10.1007/BF00272811.
PMID:600262
Abstract
Apl, a gene involved in the processing of lysosomal acid phosphatase in mouse liver, has been mapped on Chromosome 17. The gene order and map distances in per cent recombination of the loci studied are T (20.6 +/- 3.4) Pgk-2 (7.4 +/- 2.2) Apl. Thus, Apl is at least 7 cM distal to H-2 on this chromosome. In addition, strain-specific allelic variants for Apl have been demonstrated on cellulose acetate gels, a quick and inexpensive method of electrophoresis.
摘要
Apl是一个参与小鼠肝脏溶酶体酸性磷酸酶加工过程的基因，已被定位在17号染色体上。所研究基因座的基因顺序和以重组百分比表示的图距为T（20.6±3.4）Pgk - 2（7.4±2.2）Apl。因此，在这条染色体上，Apl至少在H - 2远端7厘摩处。此外，在醋酸纤维素凝胶上已证实了Apl的品系特异性等位基因变体，醋酸纤维素凝胶是一种快速且廉价的电泳方法。
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