Wyczółkowska J, Sułowska Z, Brzezińska-Błaszczyk E
Department of Biogenic Amines, Polish Academy of Sciences, Lódź, Poland.
Agents Actions. 1989 Apr;27(1-2):46-8. doi: 10.1007/BF02222194.
Histamine releasing factor (HRF) generated in vitro by spleen cells of immunized mice activates homologous peritoneal mast cells (both normal and sensitized) for small but consistent, dose-dependent histamine and 5-hydroxytryptamine release. Both the time-course of this release and its susceptibility to the enhancing effect of D2O were similar to those observed in IgE-induced release; however, simultaneous challenge of sensitized mast cells with HRF and specific antigen or anti-IgE showed an additive effect, suggesting that mediator release by HRF and by the IgE system are independent of one another.
免疫小鼠脾细胞在体外产生的组胺释放因子（HRF）可激活同源腹膜肥大细胞（正常和致敏的），使其释放少量但持续且剂量依赖性的组胺和5-羟色胺。这种释放的时间进程及其对重水增强作用的敏感性与在IgE诱导的释放中观察到的相似；然而，用HRF和特异性抗原或抗IgE同时刺激致敏肥大细胞显示出相加效应，这表明HRF和IgE系统介导的介质释放彼此独立。
