黄曲霉毒素B1对大鼠肝脏的作用。
The action of aflatoxin B1 on the rat liver.
作者信息
Clifford J I, Rees K R
出版信息
Biochem J. 1967 Jan;102(1):65-75. doi: 10.1042/bj1020065.
Abstract
The administration of a single dose of aflatoxin B(1) to the rat (7mg./kg. body wt.) results in the slow development of a periportal necrosis. Hepatic enzymes are released into the serum in the second 24hr. of the poisoning, closely preceding the onset of the necrosis, which is followed by a rise in serum alkaline-phosphatase activity and bilirubin concentration. Aflatoxin B(1) has been detected in the nucleus of the poisoned liver cell and in vitro it has been shown to interact with DNA. The toxin inhibits the production of nuclear RNA, probably by preventing the transcription of DNA by the RNA polymerase. It is proposed that the interaction of the toxin with DNA gives rise to its inhibitory action on mitosis and its necrogenic action.
摘要
给大鼠单次注射黄曲霉毒素B1（7毫克/千克体重）会导致门静脉周围坏死的缓慢发展。在中毒后的第二个24小时内，肝酶会释放到血清中，紧接着坏死开始，随后血清碱性磷酸酶活性和胆红素浓度升高。在中毒肝细胞的细胞核中已检测到黄曲霉毒素B1，并且在体外已证明它与DNA相互作用。该毒素可能通过阻止RNA聚合酶对DNA的转录来抑制核RNA的产生。有人提出，毒素与DNA的相互作用导致其对有丝分裂的抑制作用和致坏死作用。
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