Nakazawa I, Asaki S, Ito S
Tohoku J Exp Med. 1977 Dec;123(4):365-70. doi: 10.1620/tjem.123.365.
Fourteen cases of gastric cancer, 9 cases of gastric polyp and 4 cases of gastric ulcer were studied on their tissues lipid-chemically with the aim to clarify the biochemical differences between malignant and benign growth of the human gastric tissue. Tissues were collected by surgical operation or a biopsy together with the normal tissues surrounding the lesions. One part of each tissue was subjected to histologic examination and the other part to lipid analyses by means of TLC and GLC. The total lipid content was dcreased in 71% of gastric cancerous cases and in 75% of both cases of gastric polyp and gastric ulcer as compared with the respective control tissues. The phospholipid fatty acid content of the lesions was decreased in 83% of cancerous cases but in 50% of polypous cases as compared with the respective control tissues. As for the phospholipid fatty acid composition, the percentage value of C20:4 was increased and the percentage value of C18:2 was decreased in gastric cancerous tissues when compared with those of gastric polypous tissues. Such a change of the phospholipid fatty acid composition may produce the change of the fluidity of the cell membrane and may provoke a malignant growth of human gastric cancer cells.
对14例胃癌、9例胃息肉和4例胃溃疡组织进行脂质化学研究，旨在阐明人胃组织恶性生长与良性生长之间的生化差异。通过手术或活检采集组织，同时采集病变周围的正常组织。每个组织的一部分进行组织学检查，另一部分通过薄层色谱法（TLC）和气相色谱法（GLC）进行脂质分析。与各自的对照组织相比，71%的胃癌病例、75%的胃息肉病例和胃溃疡病例的总脂质含量降低。与各自的对照组织相比，83%的癌性病例病变的磷脂脂肪酸含量降低，但息肉病例中这一比例为50%。至于磷脂脂肪酸组成，与胃息肉组织相比，胃癌组织中C20:4的百分比值增加，C18:2的百分比值降低。磷脂脂肪酸组成的这种变化可能会导致细胞膜流动性的改变，并可能引发人胃癌细胞的恶性生长。
