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16S核糖体RNA参与天城链霉菌、黑暗链霉菌和紫色小单孢菌等氨基糖苷类抗生素产生菌的抗性。

Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea.

作者信息

Piendl W, Böck A, Cundliffe E

出版信息

Mol Gen Genet. 1984;197(1):24-9. doi: 10.1007/BF00327918.

DOI:10.1007/BF00327918
PMID:6083433
Abstract

Resistance to aminoglycoside antibiotics in Micromonospora purpurea (the producer of gentamicin C complex), Streptomyces tenebrarius (the nebramycin producer) and Streptomyces tenjimariensis (which makes istamycin) occurs at the level of the ribosome. Reconstitution analysis has revealed, in each case, that 16S rRNA plays a critical role in determining such resistance.

摘要

紫色小单孢菌（庆大霉素C复合物的产生菌）、黑暗链霉菌（暗霉素产生菌）和天城链霉菌（产生异他霉素）对氨基糖苷类抗生素的耐药性发生在核糖体水平。重组分析表明，在每种情况下，16S核糖体RNA在决定这种耐药性方面都起着关键作用。

相似文献

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Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea.16S核糖体RNA参与天城链霉菌、黑暗链霉菌和紫色小单孢菌等氨基糖苷类抗生素产生菌的抗性。
Mol Gen Genet. 1984;197(1):24-9. doi: 10.1007/BF00327918.
2
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4
Mechanism of resistance to aminoglycoside antibiotics in nebramycin-producing Streptomyces tenebrarius.产生暗霉素的黑暗链霉菌对氨基糖苷类抗生素的耐药机制。
J Antibiot (Tokyo). 1982 Aug;35(8):1020-5. doi: 10.7164/antibiotics.35.1020.
5
Ribosomal resistance of an istamycin producer, Streptomyces tenjimariensis, to aminoglycoside antibiotics.
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引用本文的文献

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本文引用的文献

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Resistance mechanisms of kanamycin-, neomycin-, and streptomycin-producing streptomycetes to aminoglycoside antibiotics.产生卡那霉素、新霉素和链霉素的链霉菌对氨基糖苷类抗生素的耐药机制。
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Ribosomal resistance of an istamycin producer, Streptomyces tenjimariensis, to aminoglycoside antibiotics.
Biochem Biophys Res Commun. 1981 Jun 16;100(3):1396-401. doi: 10.1016/0006-291x(81)91979-3.
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Mechanism of resistance to aminoglycoside antibiotics in nebramycin-producing Streptomyces tenebrarius.产生暗霉素的黑暗链霉菌对氨基糖苷类抗生素的耐药机制。
从石榴链霉菌抗链霉素突变体中分离的核糖体翻译准确性的体外测定。
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Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea.由庆大霉素产生菌紫色小单孢菌的DNA所确定的16S核糖体RNA甲基化以及对氨基糖苷类抗生素庆大霉素和卡那霉素的抗性。
Mol Gen Genet. 1985;201(2):168-73. doi: 10.1007/BF00425655.
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Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis.携带天蓝色链霉菌DNA的淡紫灰链霉菌克隆中16S核糖体RNA的甲基化及对氨基糖苷类抗生素的抗性
Mol Gen Genet. 1985;200(3):415-21. doi: 10.1007/BF00425725.
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RRP1, a Saccharomyces cerevisiae gene affecting rRNA processing and production of mature ribosomal subunits.RRP1，一种影响酵母核糖体RNA加工及成熟核糖体亚基产生的酿酒酵母基因。
J Bacteriol. 1987 Apr;169(4):1571-8. doi: 10.1128/jb.169.4.1571-1578.1987.
7
Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus.来自龟裂链霉菌巴龙霉素变种的氨基环醇乙酰转移酶基因的分离与核苷酸测序。
J Bacteriol. 1989 Jan;171(1):321-8. doi: 10.1128/jb.171.1.321-328.1989.
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Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin.来自黑暗链霉菌的赋予庆大霉素抗性的核糖体RNA甲基化酶基因分析。
Mol Gen Genet. 1991 Oct;229(2):229-37. doi: 10.1007/BF00272160.
9
Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis.来自锡安小单孢菌的氨基糖苷类抗性决定子的克隆与特性分析
J Bacteriol. 1992 Dec;174(23):7868-72. doi: 10.1128/jb.174.23.7868-7872.1992.
J Antibiot (Tokyo). 1982 Aug;35(8):1020-5. doi: 10.7164/antibiotics.35.1020.
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Self-resistance of a Streptomyces which produces istamycins.产生异霉素的链霉菌的自身抗性
J Antibiot (Tokyo). 1981 Jul;34(7):824-9. doi: 10.7164/antibiotics.34.824.
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Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea.庆大霉素产生菌紫色小单孢菌中的核糖体抗性。
Antimicrob Agents Chemother. 1982 Aug;22(2):231-6. doi: 10.1128/AAC.22.2.231.
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Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.赋予对硫链丝菌素抗性的核糖体RNA甲基化酶的作用位点。
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Cloning of the kanamycin resistance gene from a kanamycin-producing Streptomyces species.从一种产卡那霉素的链霉菌中克隆卡那霉素抗性基因。
J Bacteriol. 1984 Jan;157(1):79-83. doi: 10.1128/jb.157.1.79-83.1984.
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Relationship between antibiotic resistance and antibiotic productivity in actinomycetes which produce aminoglycoside antibiotics.
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Cloning of antibiotic-resistance genes in Streptomyces.链霉菌中抗生素抗性基因的克隆
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Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids.链霉菌氨基糖苷磷酸转移酶基因的核苷酸序列及其与抗性质粒编码的磷酸转移酶的关系。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5190-4. doi: 10.1073/pnas.80.17.5190.