McMahon S B, Sykova E, Wall P D, Woolf C J, Gibson S J
Neurosci Lett. 1984 Dec 21;52(3):235-40. doi: 10.1016/0304-3940(84)90167-8.
Activation of cutaneous chemosensitive afferents results in the release of substances which increase the permeability of the microcirculation, producing inflammation. That this inflammation is neurogenic is readily demonstrated by antidromic electrical stimulation of afferent fibres. In the present study we have used the technique of dye extravasation to compare both qualitatively and quantitatively neurogenic extravasation skin and skeletal muscle. Plasma extravasation has been found to occur in skeletal muscle after stimulation but only at less than 10% of the levels seen in skin. We have also found that the levels of the C-fibre markers substance P and fluoride-resistant acid phosphatase are greatly reduced in muscle compared with skin nerves. These results show that there are substantial differences in the population of C-fibres supplying muscle compared with those supplying skin.
皮肤化学敏感传入神经的激活会导致一些物质的释放，这些物质会增加微循环的通透性，从而引发炎症。通过对传入纤维进行逆向电刺激，很容易证明这种炎症是神经源性的。在本研究中，我们使用染料外渗技术对神经源性外渗的皮肤和骨骼肌进行了定性和定量比较。已发现刺激后骨骼肌中会发生血浆外渗，但程度仅为皮肤中所见水平的不到10%。我们还发现，与皮肤神经相比，肌肉中C纤维标志物P物质和耐氟酸性磷酸酶的水平大幅降低。这些结果表明，与供应皮肤的C纤维群体相比，供应肌肉的C纤维群体存在显著差异。
