Asbrink E, Hovmark A, Hederstedt B
Acta Derm Venereol. 1984;64(6):506-12.
Spirochetes were recovered from the skin lesion of 1 out of 10 acrodermatitis chronica atrophicans patients (ACA). Spirochetes from this skin isolate and from Ixodes (I.) ricinus and I. dammini spirochetes were used as antigens in indirect immunofluorescence tests. All sera from 17 ACA patients showed high antibody titers to the three antigens. Seven of the 17 sera which had the highest titers had crossreactive antibodies to treponemal antigen detectable in the FTA-ABS test. The results indicate that spirochetes are of importance for ACA and probably the causative agent of this disease. The connection between ACA and tick bites and the relationship to erythema chronicum migrans Afzelius (ECMA) and Lyme disease are discussed. The results are consistent with the hypothesis that ECMA and ACA are different manifestations of the same spirochete, with ACA as a late manifestation.
在10例进行性色素性紫癜性皮病（ACA）患者中，有1例的皮肤损害处分离出了螺旋体。来自该皮肤分离株的螺旋体以及蓖麻硬蜱和达敏硬蜱的螺旋体被用作间接免疫荧光试验的抗原。17例ACA患者的所有血清对这三种抗原均显示出高抗体滴度。17份滴度最高的血清中有7份在荧光密螺旋体抗体吸收试验（FTA - ABS）中可检测到对梅毒螺旋体抗原的交叉反应性抗体。结果表明，螺旋体对ACA很重要，可能是该疾病的病原体。文中讨论了ACA与蜱叮咬之间的联系以及与慢性游走性红斑阿费利乌斯（ECMA）和莱姆病的关系。这些结果与以下假设一致，即ECMA和ACA是同一螺旋体的不同表现形式，ACA为晚期表现。
