克罗恩病中性粒细胞氧化代谢的部分缺陷
Partial defect of neutrophil oxidative metabolism in Crohn's disease.
作者信息
Verspaget H W, Mieremet-Ooms M A, Weterman I T, Peña A S
出版信息
Gut. 1984 Aug;25(8):849-53. doi: 10.1136/gut.25.8.849.
Abstract
Polymorphonuclear leucocytes of patients with untreated Crohn's disease showed a lower level of oxidative metabolism than polymorphonuclear leucocytes of treated Crohn's disease patients and controls. Whereas the production of superoxide anion (O-.2) in Crohn's disease patients was almost normal, polymorphonuclear leucocytes of untreated Crohn's disease patients showed a significantly deficient production of hydrogen peroxide (H2O2). In the medically treated Crohn's disease patients, a significant negative correlation was found between H2O2 production by polymorphonuclear leucocytes and disease activity. These findings suggest an intrinsic cellular defect in the neutrophils of Crohn's disease patients which, together with the decreased locomotor function of these cells in vivo, might contribute to the pathogenesis of the chronic inflammation and granuloma formation in this disease.
摘要
未经治疗的克罗恩病患者的多形核白细胞显示出比接受治疗的克罗恩病患者及对照组的多形核白细胞更低水平的氧化代谢。虽然克罗恩病患者中超氧阴离子（O₂⁻）的产生几乎正常，但未经治疗的克罗恩病患者的多形核白细胞显示出过氧化氢（H₂O₂）产生明显不足。在接受药物治疗的克罗恩病患者中，多形核白细胞产生H₂O₂的量与疾病活动度之间存在显著负相关。这些发现提示克罗恩病患者的中性粒细胞存在内在细胞缺陷，这与这些细胞在体内运动功能的降低一起，可能促成了该疾病慢性炎症和肉芽肿形成的发病机制。
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