Abraham G, Colonno R J
J Virol. 1984 Aug;51(2):340-5. doi: 10.1128/JVI.51.2.340-345.1984.
Twenty-four human rhinovirus serotypes were grown and purified by centrifugation in metrizamide density gradients. These preparations had a lower buoyant density (1.24 g/cm3) and higher specific infectivities (1:24 to 1:240) than did rhinoviruses described previously (E. J. Stott and R. J. Killington, Annu. Rev. Microbiol. 26:503-524, 1972). Binding conditions in which the unique cellular receptors for virus attachment were saturated were determined for each serotype. Competition binding assays between pairs of serotypes allowed 20 of the 24 serotypes to be assigned to the same cellular receptor. The remaining four serotypes appeared to attach to a different cellular receptor. Since most serotypes were chosen for study at random, it seems likely that many of the yet unstudied rhinoviruses will share this common cellular receptor.
24种人鼻病毒血清型通过在甲泛葡胺密度梯度中离心进行培养和纯化。这些制剂的浮力密度较低（1.24 g/cm³），比先前描述的鼻病毒具有更高的比感染性（1:24至1:240）（E. J. 斯托特和R. J. 基林顿，《微生物学年评》26:503 - 524，1972）。针对每种血清型确定了使病毒附着的独特细胞受体饱和的结合条件。血清型对之间的竞争结合试验使24种血清型中的20种被归为同一细胞受体。其余四种血清型似乎附着于不同的细胞受体。由于大多数血清型是随机选择进行研究的，所以很可能许多尚未研究的鼻病毒将共享这种共同的细胞受体。
