银屑病皮肤损害鳞屑中的白三烯B4样物质。
Leukotriene B4-like material in scale of psoriatic skin lesions.
作者信息
Brain S D, Camp R D, Cunningham F M, Dowd P M, Greaves M W, Black A K
出版信息
Br J Pharmacol. 1984 Sep;83(1):313-7. doi: 10.1111/j.1476-5381.1984.tb10148.x.
Abstract
Acidic lipid extracts of scale from the lesions of the skin disease, psoriasis, were purified by straight phase high performance liquid chromatography (h.p.l.c.). Assay of fractions by an agarose microdroplet chemokinesis method showed the presence of biologically active material that coeluted with standard leukotriene B4 (LTB4). LTB4-like chemokinetic activity was also detected in fractions collected on reversed phase h.p.l.c. of psoriatic scale extracts that were initially purified by straight phase h.p.l.c. No LTB4-like activity was detected after similar purification of scale obtained by abrasion of large areas of normal skin. The LTB4-like material found in extracts of psoriatic scale may play a role in the pathogenesis of the neutrophil infiltrate which characterizes psoriasis.
摘要
采用正相高效液相色谱法（h.p.l.c.）对皮肤病银屑病皮损处鳞屑的酸性脂质提取物进行纯化。通过琼脂糖微滴趋化性方法对各馏分进行检测，结果显示存在与标准白三烯B4（LTB4）共洗脱的生物活性物质。在最初经正相h.p.l.c.纯化的银屑病鳞屑提取物的反相h.p.l.c.收集的馏分中也检测到了LTB4样趋化活性。对通过大面积正常皮肤擦伤获得的鳞屑进行类似纯化后，未检测到LTB4样活性。银屑病鳞屑提取物中发现的LTB4样物质可能在银屑病特征性的中性粒细胞浸润的发病机制中起作用。
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