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与疣状表皮发育不良相关的9种新确认的人乳头瘤病毒基因组的分子克隆与特性分析

Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis.

作者信息

Kremsdorf D, Favre M, Jablonska S, Obalek S, Rueda L A, Lutzner M A, Blanchet-Bardon C, Van Voorst Vader P C, Orth G

出版信息

J Virol. 1984 Dec;52(3):1013-8. doi: 10.1128/JVI.52.3.1013-1018.1984.

DOI:10.1128/JVI.52.3.1013-1018.1984
PMID:6092701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254633/
Abstract

The genomes of 11 human papillomaviruses (HPVs) found in benign lesions of eight patients suffering from epidermodysplasia verruciformis were cloned in Escherichia coli after insertion into plasmid pBR322. The study of the sensitivity of the cloned HPV DNAs to 14 restriction endonucleases permitted the construction of physical maps. DNA-DNA hybridization experiments, performed under stringent conditions, showed that these viruses represent nine new types, HPVs 14 (with subtypes a and b), 15, 17 (with subtypes a and b), 19, 20, 21, 22, 23, and 24. These HPVs were divided into three groups based on an absent or very weak cross-hybridization among the genomes of the viruses belonging to different groups.

摘要

从8例疣状表皮发育不良患者的良性病变中发现的11种人乳头瘤病毒（HPV）基因组，插入质粒pBR322后在大肠杆菌中克隆。对克隆的HPV DNA对14种限制性内切酶的敏感性研究使得构建物理图谱成为可能。在严格条件下进行的DNA-DNA杂交实验表明，这些病毒代表9种新类型，即HPV 14（有a和b亚型）、15、17（有a和b亚型）、19、20、21、22、23和24。根据不同组病毒基因组间不存在或非常弱的交叉杂交，将这些HPV分为三组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/254633/0665f0a57559/jvirol00129-0303-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/254633/0d1e05c2bbe4/jvirol00129-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/254633/0665f0a57559/jvirol00129-0303-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/254633/0d1e05c2bbe4/jvirol00129-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b656/254633/0665f0a57559/jvirol00129-0303-a.jpg

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