Haramaki Y, Nakayama I, Matsuo N, Uchida K, Shirakawa K
Jpn J Antibiot. 1984 Dec;37(12):2397-405.
Fundamental and clinical evaluation on ceftriaxone (Ro 13-9904, CTRX), a new cephalosporin antibiotic, was performed in the field of obstetrics and gynecology and the following results were obtained. The concentration of CTRX after intravenous injection was determined in the arterial and venous blood, and in the internal genital organs and a favorable tissue transfer was observed. The clinical efficacy rate was not very high (40%); good in 2 out of 5 cases with gyneco-obstetric infections, but it is notable that efficacy was recognized in the case which B. fragilis was detected. Neither adverse reaction nor laboratory test abnormality was seen to be attributable to CTRX in any case.
对一种新型头孢菌素抗生素头孢曲松（Ro 13-9904，CTRX）进行了妇产科领域的基础和临床评估，获得了以下结果。测定了静脉注射后CTRX在动脉血、静脉血以及内生殖器中的浓度，观察到其具有良好的组织转移。临床有效率不是很高（40%）；在5例妇产科感染病例中有2例效果良好，但值得注意的是，在检测到脆弱拟杆菌的病例中也确认了疗效。在任何情况下，均未发现任何不良反应或实验室检查异常可归因于CTRX。
