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采用阴离子交换萃取技术的头孢唑肟高效液相色谱分析法

High-pressure liquid chromatographic assay of ceftizoxime with an anion-exchange extraction technique.

作者信息

Fasching C E, Peterson L R, Bettin K M, Gerding D N

出版信息

Antimicrob Agents Chemother. 1982 Aug;22(2):336-7. doi: 10.1128/AAC.22.2.336.

DOI:10.1128/AAC.22.2.336
PMID:6100429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC183737/
Abstract

An anion-exchange extraction method was used in conjunction with high-pressure liquid chromatography for assay of ceftizoxime in 181 serum samples. Comparison of this method with bioassay gave a linear regression line described by Y = 1.11 + 0.98 X, with a correlation coefficient of 0.984. The anion-exchange extraction method is a fast, reliable method of preparing serum samples containing ceftizoxime for assay by liquid chromatography.

摘要

采用阴离子交换萃取法结合高压液相色谱法对181份血清样本中的头孢唑肟进行检测。将该方法与生物测定法进行比较，得到的线性回归线为Y = 1.11 + 0.98X，相关系数为0.984。阴离子交换萃取法是一种快速、可靠的方法，用于制备含头孢唑肟的血清样本以进行液相色谱检测。

相似文献

1
High-pressure liquid chromatographic assay of ceftizoxime with an anion-exchange extraction technique.采用阴离子交换萃取技术的头孢唑肟高效液相色谱分析法
Antimicrob Agents Chemother. 1982 Aug;22(2):336-7. doi: 10.1128/AAC.22.2.336.
2
Liquid chromatographic assay of ceftizoxime in sera of normal and uremic patients.正常人和尿毒症患者血清中头孢唑肟的液相色谱测定法。
Antimicrob Agents Chemother. 1984 Mar;25(3):336-8. doi: 10.1128/AAC.25.3.336.
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Determination of cefotaxime, desacetylcefotaxime, cefmenoxime and ceftizoxime in biological samples by fluorescence detection after separation by thin-layer chromatography.薄层色谱分离后荧光检测法测定生物样品中的头孢噻肟、去乙酰头孢噻肟、头孢甲肟和头孢唑肟
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引用本文的文献

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Antimicrob Agents Chemother. 1984 May;25(5):545-52. doi: 10.1128/AAC.25.5.545.
2
Liquid chromatographic assay of ceftizoxime in sera of normal and uremic patients.正常人和尿毒症患者血清中头孢唑肟的液相色谱测定法。
Antimicrob Agents Chemother. 1984 Mar;25(3):336-8. doi: 10.1128/AAC.25.3.336.
3
Pharmacokinetics, protein binding, and extravascular distribution of ceftizoxime in normal subjects.头孢唑肟在正常受试者中的药代动力学、蛋白结合及血管外分布
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Antimicrob Agents Chemother. 1982 Nov;22(5):844-7. doi: 10.1128/AAC.22.5.844.
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Ceftizoxime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.头孢唑肟：抗菌活性、药代动力学特性及治疗用途综述
Drugs. 1985 Apr;29(4):281-329. doi: 10.2165/00003495-198529040-00001.
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Antimicrob Agents Chemother. 1987 Aug;31(8):1157-63. doi: 10.1128/AAC.31.8.1157.

本文引用的文献

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Anion-exchange extraction of cephapirin, cefotaxime, and cefoxitin from serum for liquid chromatography.用于液相色谱分析的从血清中阴离子交换萃取头孢匹林、头孢噻肟和头孢西丁。
Antimicrob Agents Chemother. 1982 Apr;21(4):628-33. doi: 10.1128/AAC.21.4.628.
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The assay of antimicrobial compounds.
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