HLA限制的针对活流感疫苗和灭活流感疫苗的病毒特异性细胞毒性T淋巴细胞反应。

HLA restricted virus-specific cytotoxic T-lymphocyte responses to live and inactivated influenza vaccines.

作者信息

Ennis F A, Rook A H, Qi Y H, Schild G C, Riley D, Pratt R, Potter C W

出版信息

Lancet. 1981 Oct 24;2(8252):887-91. doi: 10.1016/s0140-6736(81)91389-1.

Abstract

36 young adult volunteers were given either virus, or inactivated surface-antigen influenza vaccine, containing influenza A (H1N1) antigen. Their peripheral-blood lymphocytes were analysed to determine whether cytotoxic T lymphocytes (CTL) were induced by these vaccines. All three vaccines induced HLA-restricted T-lymphocyte responses specific for influenza A virus. This CTL response was found in 28 of 30 volunteers who showed antibody responses and in 3 of 6 who did not develop antibodies. Virus infected target cells showing certain HLA antigens (A1, A9, and B8) were less susceptible to lysis by HLA-matched cytotoxic T effector cells than target cells which matched effectors at other HLA loci.

摘要

36名年轻成年志愿者被接种了病毒或含有甲型流感病毒（H1N1）抗原的灭活表面抗原流感疫苗。对他们的外周血淋巴细胞进行分析，以确定这些疫苗是否能诱导细胞毒性T淋巴细胞（CTL）。所有三种疫苗均诱导出针对甲型流感病毒的HLA限制性T淋巴细胞反应。在出现抗体反应的30名志愿者中的28名以及未产生抗体的6名志愿者中的3名中发现了这种CTL反应。与在其他HLA位点与效应细胞匹配的靶细胞相比，显示某些HLA抗原（A1、A9和B8）的病毒感染靶细胞对HLA匹配的细胞毒性T效应细胞的裂解更不敏感。