人类对甲型流感疫苗接种的细胞毒性T细胞反应。
The human cytotoxic T cell response to influenza A vaccination.
作者信息
McMichael A J, Gotch F, Cullen P, Askonas B, Webster R G
出版信息
Clin Exp Immunol. 1981 Feb;43(2):276-84.
Abstract
The human cytotoxic T lymphocyte (CTL) response to challenge with influenza A vaccine was studied. Six of eight volunteers given killed whole influenza virus A/USSR (H1N1) vaccine showed substantial increases on the level of CTL memory 1 month after immunization. The CTL measured at this time showed complete cross-reactivity in their specificity for influenza A/USSR (H1N1) and A/X31 (H3N2) infected cells and also showed HLA restriction. The level of CTL memory increased in only three out of nine donors given subunit vaccine and showed no change in those not given vaccine. If cytotoxic T cells are important in influenza prophylaxis, killed whole virus vaccine should offer better protection than subunit vaccine.
摘要
对甲型流感疫苗激发的人类细胞毒性T淋巴细胞（CTL）反应进行了研究。八名接种甲型流感病毒A/苏联（H1N1）灭活全病毒疫苗的志愿者中，有六人在免疫后1个月时CTL记忆水平显著升高。此时检测到的CTL对感染甲型流感病毒A/苏联（H1N1）和A/X31（H3N2）的细胞具有完全交叉反应性，并且还表现出HLA限制性。九名接种亚单位疫苗的供体中只有三人的CTL记忆水平有所升高，而未接种疫苗的供体则无变化。如果细胞毒性T细胞在流感预防中起重要作用，那么灭活全病毒疫苗应比亚单位疫苗提供更好的保护。
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