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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Basson A B, Terblanche S E, Oelofsen W

Comp Biochem Physiol A Comp Physiol. 1982;71(3):369-74. doi: 10.1016/0300-9629(82)90420-0.

A modified procedure, based on the autofluorescent properties of the age pigment, lipofuscin, has been applied to obtain quantitative data on the accumulation of the proteolipid fraction of the pigment in a variety of tissues of the rat (Rattus norvegicus). The tissues investigated included muscle (fast-twitch white and red fibers), heart, brain and spleen. 2. The effects of a life-long treadmill training program on the concentration of lipofuscin in the different tissues, was determined in a cross-sectional study at various ages between 41/2 and 19 months. 3. All the tissues investigated revealed an increase in the concentration of lipofuscin with training. The increase exceeded the increment observed in ageing control animals. 4. It is postulated that the elevated lipofuscin levels observed with physical training reflect an ultrastructural adaptive change in the cells. A relative deficiency of oxygen in the tissues could be the important metabolic factor triggering this mechanism.

基于老年色素脂褐素的自发荧光特性，采用一种改良方法，获取大鼠（褐家鼠）多种组织中该色素蛋白脂质部分积累的定量数据。所研究的组织包括肌肉（快肌白纤维和红纤维）、心脏、大脑和脾脏。2. 在一项横断面研究中，测定了4.5至19个月不同年龄段终身跑步机训练计划对不同组织中脂褐素浓度的影响。3. 所有研究组织均显示，训练后脂褐素浓度增加。这种增加超过了衰老对照动物中观察到的增量。4. 据推测，体育锻炼观察到的脂褐素水平升高反映了细胞的超微结构适应性变化。组织中相对缺氧可能是触发该机制的重要代谢因素。

Basson A B, Terblanche S E, Oelofsen W

Comp Biochem Physiol A Comp Physiol. 1982;71(3):369-74. doi: 10.1016/0300-9629(82)90420-0.

A modified procedure, based on the autofluorescent properties of the age pigment, lipofuscin, has been applied to obtain quantitative data on the accumulation of the proteolipid fraction of the pigment in a variety of tissues of the rat (Rattus norvegicus). The tissues investigated included muscle (fast-twitch white and red fibers), heart, brain and spleen. 2. The effects of a life-long treadmill training program on the concentration of lipofuscin in the different tissues, was determined in a cross-sectional study at various ages between 41/2 and 19 months. 3. All the tissues investigated revealed an increase in the concentration of lipofuscin with training. The increase exceeded the increment observed in ageing control animals. 4. It is postulated that the elevated lipofuscin levels observed with physical training reflect an ultrastructural adaptive change in the cells. A relative deficiency of oxygen in the tissues could be the important metabolic factor triggering this mechanism.

基于老年色素脂褐素的自发荧光特性，采用一种改良方法，获取大鼠（褐家鼠）多种组织中该色素蛋白脂质部分积累的定量数据。所研究的组织包括肌肉（快肌白纤维和红纤维）、心脏、大脑和脾脏。2. 在一项横断面研究中，测定了4.5至19个月不同年龄段终身跑步机训练计划对不同组织中脂褐素浓度的影响。3. 所有研究组织均显示，训练后脂褐素浓度增加。这种增加超过了衰老对照动物中观察到的增量。4. 据推测，体育锻炼观察到的脂褐素水平升高反映了细胞的超微结构适应性变化。组织中相对缺氧可能是触发该机制的重要代谢因素。