淋病奈瑟菌菌株P9不透明变体的相对毒力
Comparative virulence of opacity variants of Neisseria gonorrhoeae strain P9.
作者信息
Virji M, Everson J S
出版信息
Infect Immun. 1981 Mar;31(3):965-70. doi: 10.1128/iai.31.3.965-970.1981.
Abstract
The invasive properties of nine variants of Neisseria gonorrhoeae strain P9 known to vary in their surface composition have been investigated. Relative virulence was evaluated by their cytotoxic effect on Chang epithelial cell monolayers. Piliated variants P9-2 (with alpha pili) and P9-20 (with beta pili plus protein II) showed increased ability to kill the target cells compared with the prototype P9-1 (lacking pili and additional outer membrane proteins). Two nonpiliated variants, P9-11 (with proteins IIa and IId) and P9-19 (with proteins II and IIc), were also relatively more virulent compared with P9-1. Enhanced attachment was exhibited by both piliated and some nonpiliated variants: beta-piliated P9-20 (with protein II; molecular weight, 29,000) and nonpiliated P9-16 (with protein IIb; molecular weight, 28,000) were the most effective in adherence to the target monolayers.
摘要
对已知表面成分不同的淋病奈瑟菌菌株P9的9种变体的侵袭特性进行了研究。通过它们对Chang上皮细胞单层的细胞毒性作用来评估相对毒力。与原型P9-1（缺乏菌毛和额外的外膜蛋白）相比，有菌毛的变体P9-2（有α菌毛）和P9-20（有β菌毛加蛋白II）显示出更强的杀死靶细胞的能力。两种无菌毛变体P9-11（有蛋白IIa和IId）和P9-19（有蛋白II和IIc）与P9-1相比也具有相对更强的毒力。有菌毛和一些无菌毛变体均表现出增强的黏附能力：有β菌毛的P9-20（有蛋白II；分子量29,000）和无菌毛的P9-16（有蛋白IIb；分子量28,000）在黏附靶细胞单层方面最有效。
相似文献
1
Comparative virulence of opacity variants of Neisseria gonorrhoeae strain P9.淋病奈瑟菌菌株P9不透明变体的相对毒力
Infect Immun. 1981 Mar;31(3):965-70. doi: 10.1128/iai.31.3.965-970.1981.
2
The role of common and type-specific pilus antigenic domains in adhesion and virulence of gonococci for human epithelial cells.常见菌毛和型特异性菌毛抗原结构域在淋球菌对人上皮细胞的黏附及毒力中的作用。
J Gen Microbiol. 1984 May;130(5):1089-95. doi: 10.1099/00221287-130-5-1089.
3
Variations in surface protein composition associated with virulence properties in opacity types of Neisseria gonorrhoeae.
J Gen Microbiol. 1979 Oct;114(2):305-12. doi: 10.1099/00221287-114-2-305.
4
The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells.菌毛在致病性奈瑟菌与培养的人内皮细胞相互作用中的作用。
Mol Microbiol. 1991 Aug;5(8):1831-41. doi: 10.1111/j.1365-2958.1991.tb00807.x.
5
Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells.不透明外膜蛋白的相变控制淋病奈瑟菌对人上皮细胞的侵袭。
EMBO J. 1991 Jun;10(6):1307-15. doi: 10.1002/j.1460-2075.1991.tb07649.x.
6
Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoeae and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells.PilC和PilE蛋白在淋病奈瑟菌和脑膜炎奈瑟菌菌毛介导的对人红细胞、内皮细胞及上皮细胞黏附中的作用。
Infect Immun. 1999 Feb;67(2):834-43. doi: 10.1128/IAI.67.2.834-843.1999.
7
The effect of protein II and pili on the interaction of Neisseria gonorrhoeae with human polymorphonuclear leucocytes.蛋白质II和菌毛对淋病奈瑟菌与人类多形核白细胞相互作用的影响。
J Gen Microbiol. 1986 Feb;132(2):503-12. doi: 10.1099/00221287-132-2-503.
8
Differential attachment by piliated and nonpiliated Neisseria gonorrhoeae to human sperm.有菌毛和无菌毛的淋病奈瑟菌对人类精子的差异黏附作用。
Infect Immun. 1974 May;9(5):897-902. doi: 10.1128/iai.9.5.897-902.1974.
9
Effect of anti-pilus antisera on virulence of variants of Neisseria gonorrhoeae for cultured epithelial cells.抗菌毛抗血清对淋病奈瑟菌变异株对培养上皮细胞毒力的影响。
J Gen Microbiol. 1982 May;128(5):1095-100. doi: 10.1099/00221287-128-5-1095.
10
The cohesive properties of variants of Neisseria gonorrhoeae strain P9: specific pilus-mediated and non-specific interactions.淋病奈瑟菌菌株P9变体的黏附特性：特定菌毛介导的相互作用和非特异性相互作用。
J Gen Microbiol. 1980 Jul;119(1):179-87. doi: 10.1099/00221287-119-1-179.
引用本文的文献
1
Bacterium of one thousand and one variants: genetic diversity of pathogenicity.一千种变体的细菌：致病性的遗传多样性。
Microb Genom. 2023 Jun;9(6). doi: 10.1099/mgen.0.001040.
2
spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF.某些物种通过三聚体自转运粘附素CbpF靶向人类癌胚抗原相关细胞粘附分子1（CEACAM1）。
J Oral Microbiol. 2019 Jan 24;11(1):1565043. doi: 10.1080/20002297.2018.1565043. eCollection 2019.
3
Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation.淋病奈瑟菌通过激活非肌肉肌球蛋白II介导的上皮脱落来感染人类子宫颈内膜。
PLoS Pathog. 2017 Apr 13;13(4):e1006269. doi: 10.1371/journal.ppat.1006269. eCollection 2017 Apr.
4
Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells.脑膜炎奈瑟菌和淋病奈瑟菌的Opa+和Opa-分离株可诱导人CD4+ T细胞产生持续的增殖反应。
Infect Immun. 2009 Nov;77(11):5170-80. doi: 10.1128/IAI.00355-09. Epub 2009 Aug 31.
5
IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.γ干扰素通过特异性上调癌胚抗原相关细胞粘附分子1，增强核因子κB依赖性的脑膜炎奈瑟菌对上皮细胞的侵袭。
Cell Microbiol. 2007 Dec;9(12):2968-83. doi: 10.1111/j.1462-5822.2007.01038.x. Epub 2007 Aug 30.
6
Interactions of Neisseria gonorrhoeae with mature human macrophage opacity proteins influence production of proinflammatory cytokines.淋病奈瑟菌与成熟人类巨噬细胞不透明蛋白的相互作用影响促炎细胞因子的产生。
Infect Immun. 2001 Mar;69(3):1909-13. doi: 10.1128/IAI.69.3.1909-1913.2001.
7
Modulation of gonococcal piliation by regulatable transcription of pilE.通过pilE的可调节转录对淋球菌菌毛形成的调控
J Bacteriol. 2001 Mar;183(5):1600-9. doi: 10.1128/JB.183.5.1600-1609.2001.
8
Effects of the immunoglobulin A1 protease on Neisseria gonorrhoeae trafficking across polarized T84 epithelial monolayers.免疫球蛋白A1蛋白酶对淋病奈瑟菌穿越极化T84上皮单层细胞转运的影响。
Infect Immun. 2000 Feb;68(2):906-11. doi: 10.1128/IAI.68.2.906-911.2000.
9
Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases.奈瑟菌孔蛋白（PorB）可导致靶细胞中钙离子快速内流，并通过激活半胱氨酸蛋白酶诱导细胞凋亡。
EMBO J. 1999 Jan 15;18(2):339-52. doi: 10.1093/emboj/18.2.339.
10
Comparisons between colony phase variation of Neisseria gonorrhoeae FA1090 and pilus, pilin, and S-pilin expression.淋病奈瑟菌FA1090的菌落相变与菌毛、菌毛蛋白和S-菌毛蛋白表达之间的比较。
Infect Immun. 1998 May;66(5):1918-27. doi: 10.1128/IAI.66.5.1918-1927.1998.
本文引用的文献
1
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
2
Biological properties of two distinct pilus types produced by isogenic variants of Neisseria gonorrhoeae P9.淋病奈瑟菌P9同基因变体产生的两种不同菌毛类型的生物学特性
J Bacteriol. 1980 Jan;141(1):393-6. doi: 10.1128/jb.141.1.393-396.1980.
3
Neisseria gonorrhoeae 3. Demonstration of presumed appendages to cells from different colony types.淋病奈瑟菌 3. 不同菌落类型细胞上假定附属物的展示。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(3):437-9. doi: 10.1111/j.1699-0463.1971.tb00086.x.
4
Gonococci in urethral exudates possess a virulence factor lost on subculture.尿道分泌物中的淋球菌具有一种在传代培养时会丧失的毒力因子。
Nature. 1970 Jul 25;227(5256):382-4. doi: 10.1038/227382a0.
5
Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells.淋病奈瑟菌感染的研究。IV. 菌毛：它们在淋病奈瑟菌附着于组织培养细胞中的作用。
J Exp Med. 1973 Mar 1;137(3):571-89. doi: 10.1084/jem.137.3.571.
6
Effect of Neisseria gonorrhoeae on human and rabbit oviducts.淋病奈瑟菌对人及兔输卵管的影响。
Br J Vener Dis. 1974 Aug;50(4):279-88. doi: 10.1136/sti.50.4.279.
7
The human fallopian tube: a laboratory model for gonococcal infection.人类输卵管：淋球菌感染的实验室模型。
J Infect Dis. 1974 Jun;129(6):650-9. doi: 10.1093/infdis/129.6.650.
8
Role of pili in the virulence of Neisseria gonorrhoeae.菌毛在淋病奈瑟菌毒力中的作用。
Infect Immun. 1973 Aug;8(2):255-63. doi: 10.1128/iai.8.2.255-263.1973.
9
Studies on gonococcus infection. I. Pili and zones of adhesion: their relation to gonococcal growth patterns.淋病奈瑟菌感染的研究。I. 菌毛与黏附区：它们与淋病奈瑟菌生长模式的关系。
J Exp Med. 1971 Oct 1;134(4):886-906. doi: 10.1084/jem.134.4.886.
10
The influence of surface charge on the attachment of Neisseria gonorrhoeae to human cells.
J Gen Microbiol. 1976 Oct;96(2):359-64. doi: 10.1099/00221287-96-2-359.
Zotero 插件