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百日咳博德特氏菌血清型特异性凝集原与菌毛之间的抗原关系。

Antigenic relationship between serotype-specific agglutinogen and fimbriae of Bordetella pertussis.

作者信息

Ashworth L A, Irons L I, Dowsett A B

出版信息

Infect Immun. 1982 Sep;37(3):1278-81. doi: 10.1128/iai.37.3.1278-1281.1982.

DOI:10.1128/iai.37.3.1278-1281.1982
PMID:6127315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347675/
Abstract

The widely held view that the filamentous hemagglutinin (FHA) of Bordetella pertussis is derived from fimbriae (pili) is not supported by studies of fimbriation and FHA content of the organism. Fimbriae do not label specifically with antibody to FHA in immuno-electron microscopy but do label with antibody to serotype-specific agglutinogen.

摘要

广泛持有的观点认为百日咳博德特氏菌的丝状血凝素（FHA）源自菌毛，但该生物体的菌毛形成和FHA含量研究并不支持这一观点。在免疫电子显微镜下，菌毛不会用抗FHA抗体进行特异性标记，但会用抗血清型特异性凝集原的抗体进行标记。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/347675/fe74d180943c/iai00150-0444-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/347675/fe74d180943c/iai00150-0444-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/347675/fe74d180943c/iai00150-0444-a.jpg

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本文引用的文献

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Rabbit nasopharyngeal colonization by Bordetella pertussis: the effects of immunization on clearance and on serum and nasal antibody levels.百日咳博德特氏菌在兔鼻咽部的定植：免疫对清除以及血清和鼻腔抗体水平的影响。
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Leukocytosis-promoting factor of Bordetella pertussis. 3. Its identity with protective antigen.百日咳博德特氏菌的促白细胞增多因子。3. 其与保护性抗原的一致性。
Infect Immun. 1974 May;9(5):801-10. doi: 10.1128/iai.9.5.801-810.1974.
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Purified K-agglutinogen of Bordetella pertussis and its properties.
Clin Vaccine Immunol. 2014 May;21(5):636-40. doi: 10.1128/CVI.00760-13. Epub 2014 Mar 5.
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Production and characterization of recombinant pertactin, fimbriae 2 and fimbriae 3 from Bordetella pertussis.重组百日咳博德特氏菌 pertactin、菌毛 2 和菌毛 3 的生产与特性。
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Use of monoclonal antibodies to serotype Bordetella pertussis isolates: comparison of results obtained by indirect whole-cell enzyme-linked immunosorbent assay and bacterial microagglutination methods.使用单克隆抗体对百日咳博德特氏菌分离株进行血清分型：间接全细胞酶联免疫吸附测定法与细菌微量凝集法所得结果的比较
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Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada.加拿大分离的百日咳博德特氏菌菌株菌毛fim3基因的多态性
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Rapid typing of Bordetella pertussis pertussis toxin gene variants by LightCycler real-time PCR and fluorescence resonance energy transfer hybridization probe melting curve analysis.利用LightCycler实时荧光定量PCR及荧光共振能量转移杂交探针熔解曲线分析快速鉴定百日咳博德特氏菌百日咳毒素基因变异体
J Clin Microbiol. 2002 Jun;40(6):2213-6. doi: 10.1128/JCM.40.6.2213-2216.2002.
8
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J Clin Microbiol. 2001 Nov;39(11):4220. doi: 10.1128/JCM.39.11.4220.2001.
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百日咳博德特氏菌纯化的K凝集原及其特性。
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Studies on the ultrastructure of Bordetella pertussis. I. Morphology, origin, and biological activity of structures present in the extracellular fluid of liquid cultures of Bordetella pertussis.百日咳博德特氏菌的超微结构研究。I. 百日咳博德特氏菌液体培养物细胞外液中结构的形态、起源及生物活性
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Infect Immun. 1979 Aug;25(2):764-7. doi: 10.1128/iai.25.2.764-767.1979.