白三烯B4，痛风中的一种炎症介质。
Leukotriene B4, an inflammatory mediator in gout.
作者信息
Rae S A, Davidson E M, Smith M J
出版信息
Lancet. 1982 Nov 20;2(8308):1122-4. doi: 10.1016/s0140-6736(82)92785-4.
Leukotriene B4 (LTB4), a metabolite of arachidonic acid and a potent cytotaxin, is generated by human peripheral polymorphonuclear leucocytes (PMNs) exposed to monosodium urate crystals (MSU). The leukotriene is present in gouty effusions in concentrations significantly greater than those found in synovial fluid from patients with active rheumatoid arthritis or osteoarthritis. Further metabolism and biological deactivation of LTB4 by PMNs are partly inhibited by MSU. It is concluded that LTB4 is an important chemical mediator in an acute gouty attack.
白三烯B4（LTB4）是花生四烯酸的一种代谢产物，也是一种强效细胞趋化因子，由暴露于尿酸钠晶体（MSU）的人外周多形核白细胞（PMN）产生。在痛风性关节腔积液中，白三烯的浓度明显高于类风湿性关节炎或骨关节炎患者的滑液。PMN对LTB4的进一步代谢和生物失活作用部分受到MSU的抑制。由此得出结论，LTB4是急性痛风发作的一种重要化学介质。
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