Gillin J C
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):351-64. doi: 10.1016/0278-5846(83)90123-9.
This paper reviews five different types of deliberate sleep-wake manipulations which are reported to have antidepressant effects: total sleep deprivation, partial sleep deprivation, a phase advance of the sleep periods, and REM deprivation. The effects of total sleep deprivation are best documented. Of 852 depressed patients studied, 493 or 57.9% improved following sleep deprivation. The REM deprivation procedure acts more slowly, but is of more lasting clinical value than the other forms. Partial sleep deprivation during the second half of the night may be as good as total sleep deprivation and better tolerated. The findings are reviewed in terms of psychological, neurophysiological, biochemical, and chronobiological perspectives.
本文综述了据报道具有抗抑郁作用的五种不同类型的故意睡眠-觉醒干预措施：完全睡眠剥夺、部分睡眠剥夺、睡眠时间的提前以及快速眼动睡眠剥夺。完全睡眠剥夺的效果有最充分的文献记载。在研究的852名抑郁症患者中，493名（57.9%）在睡眠剥夺后病情有所改善。快速眼动睡眠剥夺程序起效较慢，但比其他形式具有更持久的临床价值。夜间后半段的部分睡眠剥夺可能与完全睡眠剥夺效果相同，且耐受性更好。从心理学、神经生理学、生物化学和时间生物学的角度对这些研究结果进行了综述。
