Li Bo-Zhi, Cao Ya, Zhang Ying, Chen Yang, Gao Yu-Hong, Peng Jia-Xi, Shao Yong-Cong, Zhang Xi
Department of Neurology, Secondary Medical Center, National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing, China.
Department of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Front Neurol. 2021 Feb 26;12:642411. doi: 10.3389/fneur.2021.642411. eCollection 2021.
The thalamus is a key node for sleep-wake pathway gate switching during acute sleep deprivation (ASD), and studies have shown that it plays a certain role in emotion changes. However, there are no studies on the association between the thalamus and emotion changes in ASD. In this study, we used resting-state functional magnetic resonance imaging (R-fMRI) to explore whether changes in the functional connections between the thalamus and other brain regions are related to emotion changes and further explored the function of the thalamus under total ASD conditions. Thirty healthy, right-handed adult men underwent emotional assessment according to the Profile of Mood States Scale and R-fMRI scans before and after ASD. The correlations between changes in functional connectivity between the thalamus and other brain regions and emotion changes were then studied. Positive emotions and psychomotor performance were reduced, and negative emotions were increased following ASD. The functional connections between the left thalamus and left middle temporal gyrus, left inferior frontal gyrus, right thalamus, right inferior temporal gyrus, left middle temporal pole gyrus, right calcarine, left cuneus, left rectus and left medial superior frontal gyrus were significantly altered. Decreased functional connectivity between left thalamus and left inferior frontal gyrus related to emotion changes following ASD. This study finds that functional changes in the thalamus are associated with emotion changes during ASD, suggesting that the left thalamus probably plays an essential role in emotion changes under ASD conditions.
丘脑是急性睡眠剥夺（ASD）期间睡眠-觉醒通路门控切换的关键节点，研究表明其在情绪变化中起一定作用。然而，尚无关于ASD中丘脑与情绪变化之间关联的研究。在本研究中，我们使用静息态功能磁共振成像（R-fMRI）来探究丘脑与其他脑区之间功能连接的变化是否与情绪变化相关，并进一步探究在完全ASD条件下丘脑的功能。30名健康的右利手成年男性在ASD前后根据情绪状态量表进行情绪评估并接受R-fMRI扫描。然后研究丘脑与其他脑区之间功能连接变化与情绪变化之间的相关性。ASD后积极情绪和精神运动表现降低，消极情绪增加。左侧丘脑与左侧颞中回、左侧额下回、右侧丘脑、右侧颞下回、左侧颞中极回、右侧距状裂、左侧楔叶、左侧直回和左侧额上回内侧之间的功能连接发生显著改变。ASD后左侧丘脑与左侧额下回之间功能连接的降低与情绪变化相关。本研究发现，ASD期间丘脑的功能变化与情绪变化相关，提示左侧丘脑可能在ASD条件下的情绪变化中起重要作用。
