Borch-Johnsen K, Joner G, Mandrup-Poulsen T, Christy M, Zachau-Christiansen B, Kastrup K, Nerup J
Lancet. 1984 Nov 10;2(8411):1083-6. doi: 10.1016/s0140-6736(84)91517-4.
The variations in incidence rates of insulin-dependent diabetes mellitus (IDDM) in childhood within and between genetically very similar Scandinavian populations and the variations in incidence rates with time are difficult to explain. Epidemiological data show that the incidence of childhood IDDM may now be declining and suggest an inverse correlation between breast-feeding frequency and IDDM in childhood. Case-control data show that diabetic children were breast-fed for shorter periods of time than their healthy siblings and the population at large and that a smaller proportion of diabetic children were ever breast-fed. It is postulated that insufficient breast-feeding of genetically susceptible newborn infants may lead to beta-cell infection and IDDM later in life.
在遗传上非常相似的斯堪的纳维亚人群内部以及不同人群之间，儿童期胰岛素依赖型糖尿病（IDDM）发病率的差异，以及发病率随时间的变化，都难以解释。流行病学数据表明，儿童期IDDM的发病率目前可能正在下降，并且提示母乳喂养频率与儿童期IDDM之间存在负相关。病例对照数据显示，糖尿病儿童的母乳喂养时间比其健康的兄弟姐妹及总体人群要短，而且曾经接受母乳喂养的糖尿病儿童比例更小。据推测，遗传易感性新生儿母乳喂养不足可能导致β细胞感染及日后发生IDDM。
