Cunha G R, Lung B, Reese B
Invest Urol. 1980 Jan;17(4):302-4.
Tissue recombinants prepared with epithelium of the urinary bladder of adult mice and mesenchyme of the embryonic urogenital sinus were grown as renal capsular grafts in adult male hosts. Under these conditions the bladder epithelium, which is derived embryologically from the urogenital sinus, was induced to form prostate-like acini. The relevance of this observation to McNeal's (1978) hypothesis, that the formation of prostatic acini during the development of human benign prostatic hyperplasia may be a reexpression of the embryonic inductive capacity of the prostatic stroma, is discussed.
用成年小鼠膀胱上皮和胚胎泌尿生殖窦间充质制备的组织重组体，作为肾被膜移植物在成年雄性宿主中生长。在这些条件下，胚胎学上来源于泌尿生殖窦的膀胱上皮被诱导形成前列腺样腺泡。本文讨论了这一观察结果与麦克尼尔（1978年）假说的相关性，该假说认为人类良性前列腺增生发育过程中前列腺腺泡的形成可能是前列腺基质胚胎诱导能力的重新表达。
