Wikler M, Demeur C, Dewasme G, Urbain J
J Exp Med. 1980 Oct 1;152(4):1024-35. doi: 10.1084/jem.152.4.1024.
Specific idiotypie can be induced in randomly chosen rabbits by preimmunization with anti-idiotypic antibodies (Ab2). Rabbits that synthesize anti-anti-idiotypic antibodies (Ab3) when injected with antigen produce antibodies that display idiotypic specificities that are also found on the starting idiotype. When female rabbits actively producing Ab3 are crossed with naive males, a significant proportion of the offsprings (approximately 40%) produce antibodies that were idiotypically cross-reactive with the starting idiotype, as compared to 3% of the controls. This conclusion was obtained using 5 female rabbits and their 32 surviving offspring. Maternal idiotypes have therefore strong immunoregulatory properties and influence the emergence of the available idiotypic repertoire.
通过用抗独特型抗体(Ab2)进行预免疫,可以在随机选择的兔子中诱导出特定的独特型。当注射抗原时合成抗抗独特型抗体(Ab3)的兔子产生的抗体表现出与起始独特型相同的独特型特异性。当主动产生Ab3的雌性兔子与未免疫的雄性兔子杂交时,与3%的对照组相比,相当比例的后代(约40%)产生与起始独特型具有独特型交叉反应的抗体。这一结论是通过使用5只雌性兔子及其32只存活后代得出的。因此,母源独特型具有很强的免疫调节特性,并影响可用独特型库的出现。