增殖性和辅助性T细胞活性的组织相容性需求分析。通过阴性选择去除同种反应性细胞的T细胞群体。
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.
作者信息
Shih W W, Matzinger P C, Swain S L, Dutton R W
出版信息
J Exp Med. 1980 Nov 1;152(5):1311-28. doi: 10.1084/jem.152.5.1311.
Abstract
T cell populations were prepared from donors immunized with hapten-carrier conjugates and were depleted of alloreactive cells by negative selection. This was accomplished by injection of the cells into H-2-disparate irradiated recipients and recovery from the thoracic duct after 18-40 h. The genetic requirements for the proliferative and helper activity of these populations was determined. The proliferative response to antigen presented on adherent, Thy-1-negative cells was determined, and a requirement for syngeneic antigen-presenting cells (APC) was demonstrated. The same T cells were assayed for their ability to give help to hapten primed B cells. It was shown that there was a requirement for syngeneic APC and for linked recognition of hapten and carrier determinants on the same molecule by the B cell and T cell. There was no requirement for the B cell to be H-2 compatible with the T cell. The requirement for linked recognition was taken as evidence that the responses in allogeneic combinations were not a result of positive allogeneic effects. Precisely comparable restrictions were found with positively selected cells.
摘要
从用半抗原-载体偶联物免疫的供体中制备T细胞群体，并通过阴性选择去除同种反应性细胞。这是通过将细胞注射到H-2不同的经照射受体中，并在18 - 40小时后从胸导管中回收来实现的。确定了这些群体增殖和辅助活性的遗传要求。测定了对贴壁的、Thy-1阴性细胞上呈递的抗原的增殖反应，并证明了对同基因抗原呈递细胞（APC）的需求。对相同的T细胞进行检测，以确定它们向半抗原致敏的B细胞提供辅助的能力。结果表明，需要同基因APC，并且B细胞和T细胞需要在同一分子上对半抗原和载体决定簇进行连锁识别。B细胞与T细胞不需要H-2相容。对连锁识别的需求被视为同种异体组合中反应不是阳性同种异体效应结果的证据。在阳性选择的细胞中发现了完全可比的限制。
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