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增殖性和辅助性T细胞活性的组织相容性需求分析。通过阴性选择去除同种反应性细胞的T细胞群体。

Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.

作者信息

Shih W W, Matzinger P C, Swain S L, Dutton R W

出版信息

J Exp Med. 1980 Nov 1;152(5):1311-28. doi: 10.1084/jem.152.5.1311.

DOI:10.1084/jem.152.5.1311
PMID:6159449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185998/
Abstract

T cell populations were prepared from donors immunized with hapten-carrier conjugates and were depleted of alloreactive cells by negative selection. This was accomplished by injection of the cells into H-2-disparate irradiated recipients and recovery from the thoracic duct after 18-40 h. The genetic requirements for the proliferative and helper activity of these populations was determined. The proliferative response to antigen presented on adherent, Thy-1-negative cells was determined, and a requirement for syngeneic antigen-presenting cells (APC) was demonstrated. The same T cells were assayed for their ability to give help to hapten primed B cells. It was shown that there was a requirement for syngeneic APC and for linked recognition of hapten and carrier determinants on the same molecule by the B cell and T cell. There was no requirement for the B cell to be H-2 compatible with the T cell. The requirement for linked recognition was taken as evidence that the responses in allogeneic combinations were not a result of positive allogeneic effects. Precisely comparable restrictions were found with positively selected cells.

摘要

从用半抗原-载体偶联物免疫的供体中制备T细胞群体，并通过阴性选择去除同种反应性细胞。这是通过将细胞注射到H-2不同的经照射受体中，并在18 - 40小时后从胸导管中回收来实现的。确定了这些群体增殖和辅助活性的遗传要求。测定了对贴壁的、Thy-1阴性细胞上呈递的抗原的增殖反应，并证明了对同基因抗原呈递细胞（APC）的需求。对相同的T细胞进行检测，以确定它们向半抗原致敏的B细胞提供辅助的能力。结果表明，需要同基因APC，并且B细胞和T细胞需要在同一分子上对半抗原和载体决定簇进行连锁识别。B细胞与T细胞不需要H-2相容。对连锁识别的需求被视为同种异体组合中反应不是阳性同种异体效应结果的证据。在阳性选择的细胞中发现了完全可比的限制。

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1
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.增殖性和辅助性T细胞活性的组织相容性需求分析。通过阴性选择去除同种反应性细胞的T细胞群体。
J Exp Med. 1980 Nov 1;152(5):1311-28. doi: 10.1084/jem.152.5.1311.
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引用本文的文献

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2
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J Exp Med. 1981 Oct 1;154(4):1100-15. doi: 10.1084/jem.154.4.1100.
3
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J Exp Med. 1981 Aug 1;154(2):501-16. doi: 10.1084/jem.154.2.501.
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本文引用的文献

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Two types of functionally distinct, synergizing helper T cells.两种功能不同、相互协同的辅助性T细胞。
J Immunol. 1980 Mar;124(3):1350-9.
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Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.
4
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
5
Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.跨越组织相容性屏障的合作：在H-2d环境中被抗原致敏的H2d T细胞可与H-2k B细胞合作。
J Exp Med. 1976 Dec 1;144(6):1707-11. doi: 10.1084/jem.144.6.1707.
6
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.T细胞受体、免疫反应基因及其他组织相容性基因产物的功能与相互关系。
Transplant Rev. 1975;22:175-95. doi: 10.1111/j.1600-065x.1975.tb01559.x.
7
Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.体外二次抗体应答中巨噬细胞-淋巴细胞相互作用的H-2基因复合体调控
J Exp Med. 1976 Aug 1;144(2):371-81. doi: 10.1084/jem.144.2.371.
8
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses.单克隆B细胞反应中载体特异性增强的同种异体二等分。
J Exp Med. 1975 Nov 1;142(5):1165-79. doi: 10.1084/jem.142.5.1165.
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Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.参与二次抗体应答的两种不同类型的辅助性T细胞：Ia⁺和Ia⁻辅助性T细胞的独立和协同效应
J Exp Med. 1978 Feb 1;147(2):446-58. doi: 10.1084/jem.147.2.446.
10
Negative allogeneic effects in vitro. I. Allogeneic T cells markedly suppress the secondary antibody-forming cell response.体外的同种异体阴性效应。I. 同种异体T细胞显著抑制二次抗体形成细胞反应。
J Immunol. 1977 Jun;118(6):2262-8.