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跨越组织相容性屏障的合作：在H-2d环境中被抗原致敏的H2d T细胞可与H-2k B细胞合作。

Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.

作者信息

Waldmann H, Pope H, Munro A J

出版信息

J Exp Med. 1976 Dec 1;144(6):1707-11. doi: 10.1084/jem.144.6.1707.

DOI:10.1084/jem.144.6.1707
PMID:1087330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190487/
Abstract

H-2d spleen cells derived from either tetraparental or semiallogeneic radiation bone marrow chimeras can be primed to antigen within H-2d recipients to generate helper T cells capable of cooperating in a secondary response with equal efficiency with H-2d or H-2k B cells. Thus it would seem that the cooperative act between T and B cells does not require that the T cell interacts with its target B cells by either cell interaction genes or via an altered self mechanism involving both antigen and the target B-cell I-region products. This does not preclude a requirement for associative recognition or altered self in the interaction of helper T cells with accessory cells.

摘要

来自四亲代或半同种异体辐射骨髓嵌合体的H-2d脾细胞可在H-2d受体中被抗原致敏，以产生能够在二次应答中与H-2d或H-2k B细胞以同等效率合作的辅助性T细胞。因此，T细胞与B细胞之间的协同作用似乎并不要求T细胞通过细胞相互作用基因或通过涉及抗原和靶B细胞I区产物的改变自身机制与其靶B细胞相互作用。这并不排除在辅助性T细胞与辅助细胞的相互作用中需要联合识别或改变自身。

相似文献

1
Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.跨越组织相容性屏障的合作：在H-2d环境中被抗原致敏的H2d T细胞可与H-2k B细胞合作。
J Exp Med. 1976 Dec 1;144(6):1707-11. doi: 10.1084/jem.144.6.1707.
2
Histocompatibility and T-B cell cooperation in mouse radiation chimeras.小鼠辐射嵌合体中的组织相容性与T细胞和B细胞协作
J Immunol. 1975 Dec;115(6):1607-12.
3
Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-Ficoll. A novel cell interaction pathway requiring self-recognition of accessory cell H-2 determinants by both T cells and B cells.对三硝基苯基-聚蔗糖反应中的主要组织相容性复合体限制的自身识别。一种新的细胞相互作用途径，需要T细胞和B细胞对辅助细胞H-2决定簇进行自身识别。
J Exp Med. 1983 Feb 1;157(2):486-501. doi: 10.1084/jem.157.2.486.
4
Adaptive differentiation of murine lymphocytes. II. The thymic microenvironment does not restrict the cooperative partner cell preference of helper T cells differentiating in F1 leads to F1 thymic chimeras.小鼠淋巴细胞的适应性分化。II. 胸腺微环境并不限制在F1→F1胸腺嵌合体中分化的辅助性T细胞的合作伴侣细胞偏好。
J Exp Med. 1979 Jun 1;149(6):1360-70. doi: 10.1084/jem.149.6.1360.
5
Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.利用四亲代骨髓嵌合体的细胞实现组织不相容的T淋巴细胞和B淋巴细胞的协作。
J Exp Med. 1975 Oct 1;142(4):989-97. doi: 10.1084/jem.142.4.989.
6
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.同种异体辐射骨髓嵌合体中的细胞毒性T淋巴细胞反应。嵌合宿主严格决定Ia限制性T细胞的自身 repertoire，但不决定H-2K/D限制性T细胞的自身 repertoire。
J Exp Med. 1982 Dec 1;156(6):1650-64. doi: 10.1084/jem.156.6.1650.
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Major histocompatibility complex-restricted self recognition. A monoclonal anti-I-Ak reagent blocks helper T cell recognition of self major histocompatibility complex determinants.主要组织相容性复合体限制的自身识别。一种单克隆抗I-Ak试剂可阻断辅助性T细胞对自身主要组织相容性复合体决定簇的识别。
J Exp Med. 1980 Dec 1;152(6):1779-94. doi: 10.1084/jem.152.6.1779.
8
Functional characteristics of Peyer's patch lymphoid cells. II. Lipopolysaccharide is thymus dependent.派尔集合淋巴结淋巴细胞的功能特性。II. 脂多糖依赖胸腺。
J Exp Med. 1974 Feb 1;139(2):407-13. doi: 10.1084/jem.139.2.407.
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Cytotoxic T lymphocytes specific for I region determinants do not require interactions with H-2K or D gene products.针对I区决定簇的细胞毒性T淋巴细胞不需要与H-2K或D基因产物相互作用。
J Exp Med. 1977 May 1;145(5):1387-92. doi: 10.1084/jem.145.5.1387.
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Helper function of T cells depleted of alloantigen-reactive lymphocytes by filtration through irradiated F1 hybrid recipients. I. Failure to collaborate with allogeneic B cells in a secondary response to sheep erythrocytes measured in vivo.通过照射过的F1杂交受体过滤去除同种异体抗原反应性淋巴细胞的T细胞的辅助功能。I. 在体内测量的对绵羊红细胞的二次反应中无法与同种异体B细胞协作。
J Exp Med. 1976 Sep 1;144(3):617-26. doi: 10.1084/jem.144.3.617.

引用本文的文献

1
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.增殖性和辅助性T细胞活性的组织相容性需求分析。通过阴性选择去除同种反应性细胞的T细胞群体。
J Exp Med. 1980 Nov 1;152(5):1311-28. doi: 10.1084/jem.152.5.1311.
2
Co-operation across histocompatibility differences. The role of inhibitory T cells in preventing successful T-B interaction.跨越组织相容性差异的合作。抑制性T细胞在阻止T细胞与B细胞成功相互作用中的作用。
Immunology. 1977 Jul;33(1):129-39.

本文引用的文献

1
Antibody response in genetically thymus-less nude mice injected with normal thymus cells.注射正常胸腺细胞的无胸腺裸基因小鼠的抗体反应。
J Immunol. 1971 Nov;107(5):1291-5.
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Antibody responses in athymic ('nude') mice implanted with neonatal or adult allogeneic thymus.植入新生或成年同种异体胸腺的无胸腺（“裸”）小鼠的抗体反应。
Proc Soc Exp Biol Med. 1974 Feb;145(2):351-3. doi: 10.3181/00379727-145-37808.
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Induction of antibody-forming cell clones in microcultures.微量培养中抗体形成细胞克隆的诱导。
Eur J Immunol. 1972 Aug;2(4):360-6. doi: 10.1002/eji.1830020412.
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
J Exp Med. 1973 Nov 1;138(5):1194-212. doi: 10.1084/jem.138.5.1194.
5
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
6
Histocompatibility and T-B cell cooperation in mouse radiation chimeras.小鼠辐射嵌合体中的组织相容性与T细胞和B细胞协作
J Immunol. 1975 Dec;115(6):1607-12.
7
Cooperation across the histocompatibility barrier.跨越组织相容性屏障的合作。
Nature. 1975 Dec 25;258(5537):728-30. doi: 10.1038/258728a0.
8
The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.巨噬细胞在辅助性T细胞生成中的作用。II. 巨噬细胞与T细胞相互作用以通过可溶性抗原诱导辅助性细胞的遗传控制。
J Exp Med. 1975 Aug 1;142(2):460-72. doi: 10.1084/jem.142.2.460.
9
Limiting dilution analysis of helper T-cell function.辅助性T细胞功能的有限稀释分析。
Immunology. 1975 Jun;28(6):1135-48.
10
Collaboration of allogeneic T and B lymphocytes in the primary antibody response to sheep erythrocytes in vitro.同种异体T淋巴细胞和B淋巴细胞在体外对绵羊红细胞的初次抗体反应中的协作。
J Exp Med. 1975 Oct 1;142(4):928-35. doi: 10.1084/jem.142.4.928.