跨越组织相容性屏障的合作：在H-2d环境中被抗原致敏的H2d T细胞可与H-2k B细胞合作。
Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.
作者信息
Waldmann H, Pope H, Munro A J
出版信息
J Exp Med. 1976 Dec 1;144(6):1707-11. doi: 10.1084/jem.144.6.1707.
Abstract
H-2d spleen cells derived from either tetraparental or semiallogeneic radiation bone marrow chimeras can be primed to antigen within H-2d recipients to generate helper T cells capable of cooperating in a secondary response with equal efficiency with H-2d or H-2k B cells. Thus it would seem that the cooperative act between T and B cells does not require that the T cell interacts with its target B cells by either cell interaction genes or via an altered self mechanism involving both antigen and the target B-cell I-region products. This does not preclude a requirement for associative recognition or altered self in the interaction of helper T cells with accessory cells.
摘要
来自四亲代或半同种异体辐射骨髓嵌合体的H-2d脾细胞可在H-2d受体中被抗原致敏，以产生能够在二次应答中与H-2d或H-2k B细胞以同等效率合作的辅助性T细胞。因此，T细胞与B细胞之间的协同作用似乎并不要求T细胞通过细胞相互作用基因或通过涉及抗原和靶B细胞I区产物的改变自身机制与其靶B细胞相互作用。这并不排除在辅助性T细胞与辅助细胞的相互作用中需要联合识别或改变自身。
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本文引用的文献
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Antibody responses in athymic ('nude') mice implanted with neonatal or adult allogeneic thymus.植入新生或成年同种异体胸腺的无胸腺（“裸”）小鼠的抗体反应。
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