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Production of hybridomas secreting monoclonal antibodies to the human leukocyte interferons.

作者信息

Staehelin T, Durrer B, Schmidt J, Takacs B, Stocker J, Miggiano V, Stähli C, Rubinstein M, Levy W P, Hershberg R, Pestka S

出版信息

Proc Natl Acad Sci U S A. 1981 Mar;78(3):1848-52. doi: 10.1073/pnas.78.3.1848.

DOI:10.1073/pnas.78.3.1848
PMID:6165019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC319232/
Abstract

Thirteen monoclonal antibodies to human leukocyte interferon have been obtained. They exhibit different patterns of binding to purified leukocyte interferon species that are consistent with the structural multiplicity of the human leukocyte interferons. These antibodies will be useful as probes into the structure of the human leukocyte interferons, for their purification, and for rapid assay of leukocyte interferon.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ef/319232/dfe3296cd3cc/pnas00654-0565-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ef/319232/a459e79ae046/pnas00654-0562-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ef/319232/dfe3296cd3cc/pnas00654-0565-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ef/319232/a459e79ae046/pnas00654-0562-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ef/319232/dfe3296cd3cc/pnas00654-0565-a.jpg

相似文献

1
Production of hybridomas secreting monoclonal antibodies to the human leukocyte interferons.
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1848-52. doi: 10.1073/pnas.78.3.1848.
2
[Isolation of a cellular hybrid secreting an antibody specific for human leukocyte interferon].
C R Seances Acad Sci D. 1980 Nov 24;291(11):893-6.
3
A monoclonal antibody for large-scale purification of human leukocyte interferon.一种用于大规模纯化人白细胞干扰素的单克隆抗体。
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4
Monoclonal antibodies against human fibroblast interferon.
Nature. 1981 Jun 11;291(5815):500-1. doi: 10.1038/291500a0.
5
Production and screening of cell hybrids producing a monoclonal antibody to human interferon-alpha.产生抗人α干扰素单克隆抗体的细胞杂交体的制备与筛选
J Gen Virol. 1981 Apr;53(Pt 2):257-65. doi: 10.1099/0022-1317-53-2-257.
6
Monoclonal antibodies to human leukocyte interferons: their use in assay and purification.
Tex Rep Biol Med. 1981;41:43-58.
7
Monoclonal xenogeneic antibodies to mouse leukocyte antigens: identification of macrophage-specific and other differentiation antigens.针对小鼠白细胞抗原的单克隆异种抗体：巨噬细胞特异性及其他分化抗原的鉴定
Curr Top Microbiol Immunol. 1978;81:45-50. doi: 10.1007/978-3-642-67448-8_7.
8
Production of antibodies to human interferons in mice.在小鼠体内产生针对人类干扰素的抗体。
Infect Immun. 1978 Feb;19(2):570-4. doi: 10.1128/iai.19.2.570-574.1978.
9
Monoclonal antibodies.
Sci Am. 1980 Oct;243(4):66-74. doi: 10.1038/scientificamerican1080-66.
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Monoclonal antibodies: a powerful new tool in biology and medicine.单克隆抗体：生物学和医学领域强大的新工具。
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Production and purification of monoclonal antibodies to Pisum and Avena phytochrome.豌豆和燕麦光敏素单克隆抗体的制备与纯化。
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2
Development and use of enzyme-linked immunosorbent assays (ELISA) for the detection of protein aggregates in interferon-alpha (IFN-alpha) formulations.用于检测α干扰素（IFN-α）制剂中蛋白质聚集体的酶联免疫吸附测定（ELISA）的开发与应用。
Pharm Res. 1997 Oct;14(10):1394-400. doi: 10.1023/a:1012168621337.
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Electric field-induced cell-to-cell fusion.电场诱导的细胞间融合。

本文引用的文献

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Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.含人白细胞干扰素核苷酸序列细菌质粒的构建与鉴定
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7010-3. doi: 10.1073/pnas.77.12.7010.
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Amino-terminal amino acid sequence of human leukocyte interferon.人白细胞干扰素的氨基末端氨基酸序列
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Human leukocyte interferon produced by E. coli is biologically active.由大肠杆菌产生的人白细胞干扰素具有生物活性。
J Membr Biol. 1982;67(3):165-82. doi: 10.1007/BF01868659.
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Monoclonal antibodies against murine gamma interferon.抗小鼠γ干扰素单克隆抗体
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Safety and tolerance of recombinant leukocyte A interferon in bone marrow transplant recipients.重组白细胞A干扰素在骨髓移植受者中的安全性和耐受性
Antimicrob Agents Chemother. 1983 Jun;23(6):846-51. doi: 10.1128/AAC.23.6.846.
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Orientation of a human leukocyte interferon molecule on its cell surface receptor: carboxyl terminus remains accessible to a monoclonal antibody made against a synthetic interferon fragment.人白细胞干扰素分子在其细胞表面受体上的取向：羧基末端对于针对合成干扰素片段制备的单克隆抗体仍可及。
Proc Natl Acad Sci U S A. 1983 May;80(9):2539-43. doi: 10.1073/pnas.80.9.2539.
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Production of high levels of human leukocyte interferon from a continuous human myeloblast cell culture.从人成髓细胞连续培养物中产生高水平的人白细胞干扰素。
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The nature of neutralization reaction between effector protein and monoclonal antibody: a quantitative study of neutralization characteristics of anti-interferon antibodies.效应蛋白与单克隆抗体之间中和反应的性质：抗干扰素抗体中和特性的定量研究
Immunology. 1985 Nov;56(3):489-95.
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Evolution of recurrent herpes simplex lesions. An immunohistologic study.复发性单纯疱疹皮损的演变。一项免疫组织学研究。
J Clin Invest. 1985 Jan;75(1):226-33. doi: 10.1172/JCI111678.
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Normal human epidermis contains an interferon-like protein.正常人类表皮含有一种类干扰素蛋白。
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The nucleotide sequence of a cloned human leukocyte interferon cDNA.克隆的人白细胞干扰素cDNA的核苷酸序列。
Gene. 1980 Jun;10(1):1-10. doi: 10.1016/0378-1119(80)90137-7.
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A monoclonal antibody for large-scale purification of human leukocyte interferon.一种用于大规模纯化人白细胞干扰素的单克隆抗体。
Nature. 1980 Jun 12;285(5765):446-50. doi: 10.1038/285446a0.
6
High frequencies of antigen-specific hybridomas: dependence on immunization parameters and prediction by spleen cell analysis.高频率的抗原特异性杂交瘤：对免疫参数的依赖性及通过脾细胞分析进行预测
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7
Solid-phase radioimmunoassay in antibody-coated tubes.在抗体包被管中的固相放射免疫测定。
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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Continuous cultures of fused cells secreting antibody of predefined specificity.分泌预定义特异性抗体的融合细胞的连续培养物。
Nature. 1975 Aug 7;256(5517):495-7. doi: 10.1038/256495a0.
10
Human leukocyte interferon purified to homogeneity.纯化至同质的人白细胞干扰素。
Science. 1978 Dec 22;202(4374):1289-90. doi: 10.1126/science.725605.