低致癌性小鼠乳腺肿瘤病毒BALB/cNIV小鼠的免疫学特征
Immunological characterization of a low oncogenic mouse mammary tumor virus BALB/cNIV mice.
作者信息
Vacquier J P, Cardiff R D, Blair P B
出版信息
J Virol. 1981 Oct;40(1):56-64. doi: 10.1128/JVI.40.1.56-64.1981.
Antigenic determinants of mouse mammary tumor virus (MuMTV) from the low-mammary-tumor-incidence strain BALB/cNIV were compared by competition radioimmunoassay with those of MuMTV's isolated from several high- and low-mammary-tumor-incidence mouse strains, using rabbit hyperimmune sera against BALB/cNIV MuMTV and against MuMTV from the high-mammary-tumor-incidence strain BALB/cfC3H. Using anti-BALB/cfC3H serum in competition radioimmunoassay, BALB/cNIV MuMTV lacked antigenic determinants present on MuMTV's from the BALB/cfC3H, C3H, and GR strains. With anti-BALB/cNIV serum in competition radioimmunoassay, type-specific antigenicity was detected with BALB/cNIV MuMTV. We found class-specific antigenicities on BALB/cNIV MuMTV that were shared with RIII and C3Hf MuMTV's BALB/cNIV MuMTV was reportedly derived from the C3Hf strain by infection of BALB/c mouse mammary tissue after transplantation into a (BALB/c X C3Hf)F1 hybrid followed by retransplantation into the BALB/c strain (D. R. Pitelka, K. B. DeOme, and H. A. Bern. Proc. Am Assoc. Cancer Res. 6:51, 1965). However, BALB/cNIV MuMTV contained type-specific antigens not present on C3Hf MuMTV. The possible origin of these determinants is discussed.
通过竞争放射免疫测定法，使用针对BALB/cNIV小鼠乳腺肿瘤病毒（MuMTV）以及来自高乳腺肿瘤发病率品系BALB/cfC3H的MuMTV的兔超免疫血清，比较了低乳腺肿瘤发病率品系BALB/cNIV的MuMTV与从几种高和低乳腺肿瘤发病率小鼠品系分离出的MuMTV的抗原决定簇。在竞争放射免疫测定中使用抗BALB/cfC3H血清时，BALB/cNIV MuMTV缺乏存在于来自BALB/cfC3H、C3H和GR品系的MuMTV上的抗原决定簇。在竞争放射免疫测定中使用抗BALB/cNIV血清时，检测到BALB/cNIV MuMTV具有型特异性抗原性。我们发现BALB/cNIV MuMTV上存在与RIII和C3Hf MuMTV共有的类特异性抗原性。据报道，BALB/cNIV MuMTV是通过将BALB/c小鼠乳腺组织移植到（BALB/c×C3Hf）F1杂种中，然后再移植到BALB/c品系中后，由C3Hf品系感染而产生的（D.R.皮特尔卡、K.B.德奥姆和H.A.伯恩。美国癌症研究协会会议论文集。6:51，1965）。然而，BALB/cNIV MuMTV含有C3Hf MuMTV上不存在的型特异性抗原。讨论了这些决定簇的可能起源。
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