胶原蛋白衍生肽释放肥大细胞组胺。
Collagen-derived peptides release mast cell histamine.
作者信息
Wize J, Wojtecka-Lukasik E, Maśliński S
出版信息
Agents Actions. 1986 Apr;18(1-2):262-5. doi: 10.1007/BF01988037.
The effect of collagen degradation products by bacterial (BCDP) and synovial fluid collagenase (SCDP) on histamine release from peritoneal mast cells of rat was estimated. Some BCDP as well as SCDP released 60-80% of mast cell histamine. In BCDP fraction the most active were BCDP II (m.wt. 13 kD) and BCDP III (m.wt. 6 kD). The last contained the highest percentage of hydroxyproline. As compared with bradykinin, BCDP III was about 50 fold more active as histamine releaser.
评估了细菌来源的胶原蛋白降解产物（BCDP）和滑液胶原酶（SCDP）对大鼠腹膜肥大细胞组胺释放的影响。一些BCDP以及SCDP释放了60 - 80%的肥大细胞组胺。在BCDP组分中，活性最高的是BCDP II（分子量13 kD）和BCDP III（分子量6 kD）。后者含有最高比例的羟脯氨酸。与缓激肽相比，BCDP III作为组胺释放剂的活性约高50倍。
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