Herberman R B, Ortaldo J R, Rubinstein M, Pestka S
J Clin Immunol. 1981 Jul;1(3):149-53. doi: 10.1007/BF00922756.
Augmentation of the cytolytic activity of human natural killer cells and of antibody-dependent cell-mediated cytotoxicity has been attributed to human interferons. With the purification to homogeneity of human leukocyte interferon, it became possible to test directly whether pure interferon could increase the activity of these effector cells. Treatment of purified blood mononuclear cells with pure interferon resulted in substantial increases in natural killer cell activity and in antibody-dependent cell-mediated cytotoxicity. Concentrations of 10-100 units/ml of antiviral activity were sufficient to augment appreciably natural killer cell activity.
人类干扰素已被认为可增强人类自然杀伤细胞的细胞溶解活性以及抗体依赖的细胞介导的细胞毒性。随着人类白细胞干扰素纯化至同质，就有可能直接测试纯干扰素是否能增强这些效应细胞的活性。用纯干扰素处理纯化的血液单核细胞，可使自然杀伤细胞活性和抗体依赖的细胞介导的细胞毒性大幅增加。抗病毒活性浓度为10 - 100单位/毫升就足以显著增强自然杀伤细胞活性。
