小鼠Ia抗原的结构：I-E或I-C亚区产物的部分NH2末端氨基酸序列。
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion.
作者信息
McMillan M, Cecka J M, Murphy D B, McDevitt H O, Hood L
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5135-9. doi: 10.1073/pnas.74.11.5135.
Abstract
Partial amino acid sequence of the Ia molecule encoded by the I-E or I-C (I-EC) subregion of the major histocompatibility complex of the mouse are presented. The Ia molecule appears to be comprised of two noncovalently associated polypeptides. The larger subunit, alpha, has an approximate molecular weight of 35,000 and the smaller subunit, beta, an approximate molecular weight of 28,000. Several interesting homology relationships (or the lack thereof) are apparent when the Ia polypeptides from the I-EC subregion are compared both with their counterparts from man and guinea pig and with the molecules encoded in the I-A subregion. Clearly the most impressive homology relationship is that seen between the alpha polypeptide from the I-EC subregion of mouse and its human counterpart. This is in striking contrast to the beta polypeptide, which bears no apparent homology to its human counterpart.
摘要
本文展示了小鼠主要组织相容性复合体I-E或I-C（I-EC）亚区编码的Ia分子的部分氨基酸序列。Ia分子似乎由两条非共价结合的多肽组成。较大的亚基α，分子量约为35,000，较小的亚基β，分子量约为28,000。当将来自I-EC亚区的Ia多肽与来自人和豚鼠的对应物以及I-A亚区编码的分子进行比较时，几种有趣的同源关系（或缺乏同源关系）显而易见。显然，最显著的同源关系是小鼠I-EC亚区的α多肽与其人类对应物之间的关系。这与β多肽形成鲜明对比，β多肽与其人类对应物没有明显的同源性。
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Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion.小鼠Ia抗原的结构：I-E或I-C亚区产物的部分NH2末端氨基酸序列。
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本文引用的文献
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Amino acid sequence studies on ten ribosomal proteins of Escherichia coli with an improved sequenator equipped with an automatic conversion device.利用配备自动转换装置的改进型序列分析仪对大肠杆菌的十种核糖体蛋白进行氨基酸序列研究。
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2 -Microglobulin--a free immunoglobulin domain.β2微球蛋白——一种游离免疫球蛋白结构域。
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Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor.T和B淋巴细胞的体外激活。III. 同种异体效应因子上Ia决定簇的存在。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.
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Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
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