由H-2复合体的i-E/i-C亚区所决定的小鼠Ia同种抗原的化学特性
Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.
作者信息
Silver J, Russell W A, Reis B L, Frelinger J A
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5131-4. doi: 10.1073/pnas.74.11.5131.
Abstract
Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.
摘要
针对由小鼠主要组织相容性复合体的I-E和I-C亚区所决定的同种异体抗原的同种抗血清沉淀出两种分子量分别为35,000和29,000的成分。当通过部分氨基末端测序分析这些成分时，它们与由I-A亚区所决定的两种类似大小的成分没有同源性。然而，由小鼠I-E和/或I-C亚区所决定的大链与人HLA-D区同种异体抗原的大链是同源的，尽管从这两个物种中分离出的小链没有显示出任何这种同源性。
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