Schuil P J, Rosmalen J G, Graamans K, Huizing E H
Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands.
Eur Arch Otorhinolaryngol. 1995;252(8):462-4. doi: 10.1007/BF02114751.
Calcitonin gene-related peptide (CGRP) is one of the neuropeptides that is released in the human nasal mucosa after trigeminal nerve stimulation. We investigated the in vitro effect of CGRP on the ciliary beat frequency (CBF) of human upper respiratory cilia. Ciliated epithelium of freshly removed adenoidal tissues was used in all experiments. CBF was measured using a computerized photo-electric method. The results showed that CGRP exerted a significant dose-dependent stimulation on CBF in concentrations of 10(-9)-10(-6) M (n = 10), with a maximum of 23%. Our findings indicate that CGRP in vivo may help to protect the airway epithelium by directly stimulating ciliary beat.
降钙素基因相关肽（CGRP）是三叉神经刺激后在人鼻黏膜中释放的神经肽之一。我们研究了CGRP对人上呼吸道纤毛的纤毛摆动频率（CBF）的体外作用。所有实验均使用新鲜切除的腺样体组织的纤毛上皮。使用计算机光电方法测量CBF。结果表明，CGRP在10^(-9)-10^(-6) M浓度下对CBF有显著的剂量依赖性刺激作用（n = 10），最大刺激率为23%。我们的研究结果表明，体内的CGRP可能通过直接刺激纤毛摆动来帮助保护气道上皮。
