麻风病患者和正常供体外周血单个核细胞群体中，B细胞被可溶性分枝杆菌提取物进行的T细胞依赖性多克隆激活。
T-cell-dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors.
作者信息
Fleming B, Rook G A
出版信息
Immunology. 1982 Dec;47(4):589-95.
Abstract
Soluble extracts of ultrasonically disrupted mycobacteria (including Mycobacterium leprae) cause strong T-cell-dependent, Cyclosporin A-sensitive, polyclonal B-cell activation, in human peripheral blood mononuclear cell preparations. It is not enhanced by cortisol. Cells from cases of lepromatous leprosy show no polyclonal B-cell activation in the presence of extracts of M. leprae, although they respond normally to other mycobacterial species. The polyclonal B-cell activation response to the M. leprae extract, of a small group of normal leprosy contacts, was reduced relative to that of non-contacts.
摘要
超声破碎的分枝杆菌（包括麻风分枝杆菌）的可溶性提取物，在人外周血单个核细胞制剂中可引起强烈的T细胞依赖性、环孢菌素A敏感的多克隆B细胞活化。皮质醇不会增强这种活化。麻风瘤型麻风患者的细胞，在麻风分枝杆菌提取物存在的情况下不显示多克隆B细胞活化，尽管它们对其他分枝杆菌种类反应正常。一小群正常麻风接触者对麻风分枝杆菌提取物的多克隆B细胞活化反应，相对于非接触者有所降低。
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