Drach G W, Sarig S, Randolph A D, Thorson S
Urol Res. 1982;10(4):165-8. doi: 10.1007/BF00255938.
Nucleation (Bo) and linear crystal growth (G) rates, average particle size (L1,0) and total mass (MT) of calcium oxalate dihydrate crystals were measured in artificial urine with and without polylysine, polyglutamic acid or heparin. The purpose of the study was to see if any of these polymers had effects on crystallisation similar to those created by addition of 5% natural urine to artificial urine, wherein Bo had increased but G, L1,0 and MT decreased. Polylysine addition had insignificant effects. Heparin increased Bo and decreased G, L1,0 and MT significantly, and polyglutamate had similar but more marked effects than did heparin. It is concluded that properly structured organic polymers can significantly inhibit calcium oxalate dihydrate crystallisation by paradoxical enhancement of nucleation. It is possible that such polymers may act as nucleation substrates.
在含有和不含有聚赖氨酸、聚谷氨酸或肝素的人工尿液中，测量了二水合草酸钙晶体的成核速率（Bo）和线性晶体生长速率（G）、平均粒径（L1,0）和总质量（MT）。本研究的目的是观察这些聚合物中是否有任何一种对结晶的影响类似于向人工尿液中添加5%天然尿液所产生的影响，其中Bo增加而G、L1,0和MT降低。添加聚赖氨酸的影响不显著。肝素显著增加了Bo并降低了G、L1,0和MT，而聚谷氨酸具有与肝素相似但更显著的影响。得出的结论是，结构适当的有机聚合物可以通过反常地增强成核作用来显著抑制二水合草酸钙结晶。这些聚合物有可能作为成核底物。
