Edyvane K A, Ryall R L, Mazzachi R D, Marshall V R
Urol Res. 1987;15(2):87-92. doi: 10.1007/BF00260939.
The effect of serum on calcium oxalate crystallization was studied in whole human urine. At concentrations between 0.005% to 0.10% (v/v), serum had no effect on the metastable limit of urine as detected by the Coulter Counter. However, serum caused a marked increase in the number and volume of calcium oxalate crystals deposited in response to an oxalate load. That this increase in volume reflected true deposition of calcium oxalate was confirmed by determining calcium concentration and by including control urines containing added serum but no exogenous oxalate. Analysis of particle size distributions showed that the crystals deposited in the presence of serum were smaller than those occurring in the control. Since serum did not affect the limit of metastability, the enhancement of crystal volume is unlikely to be a result of heterogeneous nucleation. We hypothesize that the apparent promotion effect of serum is due to its inhibition of crystal aggregation which increases the crystal surface area available for calcium oxalate deposition.
在全人类尿液中研究了血清对草酸钙结晶的影响。血清浓度在0.005%至0.10%（v/v）之间时，库尔特计数器检测发现血清对尿液的亚稳极限没有影响。然而，血清导致在草酸盐负荷下沉积的草酸钙晶体数量和体积显著增加。通过测定钙浓度以及加入含血清但无外源草酸盐的对照尿液，证实了体积的增加反映了草酸钙的真实沉积。粒度分布分析表明，在血清存在下沉积的晶体比对照中的晶体小。由于血清不影响亚稳极限，晶体体积的增加不太可能是异相成核的结果。我们推测，血清的明显促进作用是由于其对晶体聚集的抑制，这增加了可用于草酸钙沉积的晶体表面积。
