Apostolov K, Barker W
Infect Immun. 1982 Dec;38(3):843-7. doi: 10.1128/iai.38.3.843-847.1982.
Diptheria toxin (DT) reversibly increases the saturation of the long-chain C18 fatty acids (C18FA) in concentrations which are at least 100-fold smaller than the concentrations which completely inhibit host cell protein synthesis. The concentrations required for induction of the increase in the saturation of the C18FA in fibroblasts are 100-fold smaller than the concentrations for the epithelial cells. The increase in saturation of the C18FA was proportional to the concentration of DT. A cytopathic effect appeared with DT concentrations which induced a near-maximal increase in the saturation of the C18FA, but the cells remained viable. However, at very high concentrations of DT and depending on the type of cell, there was no change in the fatty acids, and the treated cells disintegrated. Interferon, which also induces a reversible increase in the saturation of the C18FA (K. Apostolov and W. Barker, FEBS Lett. 126:261-264, 1981), produces a cumulative effect when used in conjunction with DT. This additive effect of DT and interferon is discussed in the light of other similar biological activities of these agents.
白喉毒素（DT）能可逆地增加长链C18脂肪酸（C18FA）的饱和度，其所需浓度比完全抑制宿主细胞蛋白质合成的浓度至少低100倍。在成纤维细胞中诱导C18FA饱和度增加所需的浓度比上皮细胞低100倍。C18FA饱和度的增加与DT的浓度成正比。当DT浓度诱导C18FA饱和度接近最大增加时会出现细胞病变效应，但细胞仍保持存活。然而，在非常高的DT浓度下，根据细胞类型的不同，脂肪酸没有变化，处理过的细胞会解体。干扰素也能诱导C18FA饱和度可逆增加（K. 阿波斯托洛夫和W. 巴克，《欧洲生物化学学会联合会快报》126:261 - 264，1981），与DT联合使用时会产生累积效应。根据这些试剂的其他类似生物学活性，讨论了DT和干扰素的这种相加效应。
