胞壁酰二肽增强抗原特异性抑制作用。
Enhancement of antigen-specific suppression by muramyl dipeptide.
作者信息
Ferguson T A, Krieger N J, Pesce A, Michael J G
出版信息
Infect Immun. 1983 Feb;39(2):800-6. doi: 10.1128/iai.39.2.800-806.1983.
Abstract
The effect of the synthetic adjuvant MDP (N-acetyl-muramyl-L-alanyl-D-isoglu-tamine) on the generation of antigen-specific suppression was investigated. Suppression of the anti-bovine serum albumin response, which was achieved by intravenous administration of a peptic fragment of the antigen, was greatly enhanced by simultaneous administration of MDP. Induction of suppression by a combination of bovine serum albumin fragments and MDP was found to be antigen specific and appeared to occur via the generation of antigen-specific suppressor T cells.
摘要
研究了合成佐剂MDP（N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺）对抗原特异性抑制作用的产生。通过静脉注射抗原的胃蛋白酶片段实现的抗牛血清白蛋白反应的抑制，因同时给予MDP而大大增强。发现牛血清白蛋白片段与MDP联合诱导的抑制是抗原特异性的，并且似乎是通过产生抗原特异性抑制性T细胞而发生的。
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