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相似文献

1
Enhancement of antigen-specific suppression by muramyl dipeptide.胞壁酰二肽增强抗原特异性抑制作用。
Infect Immun. 1983 Feb;39(2):800-6. doi: 10.1128/iai.39.2.800-806.1983.
2
Opposite effects of the synthetic adjuvant N-acetyl-muramyl-L-alanyl-D-isoglutamine on the immune response in mice depending on experimental conditions.合成佐剂N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺对小鼠免疫反应的相反作用取决于实验条件。
Eur J Immunol. 1980 Aug;10(8):654-6. doi: 10.1002/eji.1830100814.
3
Suppression of BCG cell wall-induced delayed-type hypersensitivity by pretreatment with killed BCG: induction of nonspecific suppressor T cells by the adjuvant portion (MDP) and of specific suppressor T cells by the antigen portion (TAP).用灭活卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用：佐剂部分（MDP）诱导非特异性抑制性T细胞，抗原部分（TAP）诱导特异性抑制性T细胞。
J Immunol. 1984 Jun;132(6):2790-5.
4
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
5
Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramyl peptides and bacterial lipopolysaccharides with bovine serum albumin.通过口服给予带有牛血清白蛋白的胞壁酰肽和亲脂性衍生物以及细菌脂多糖增强小鼠血清抗体产生。
Methods Find Exp Clin Pharmacol. 1986 Feb;8(2):117-25.
6
Enhancement by muramyl dipeptide of in vitro nude mice responses to a T-dependent antigen.胞壁酰二肽增强体外裸鼠对T细胞依赖性抗原的反应。
Immunol Commun. 1979;8(1):55-64. doi: 10.3109/08820137909044706.
7
In vivo regulation of humoral and cellular immune responses of mice by a synthetic adjuvant, N-acetyl-muramyl-L-alanyl-D-isoglutamine, muramyl dipeptide for MDP.合成佐剂N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺（胞壁酰二肽，简称MDP）对小鼠体液免疫和细胞免疫反应的体内调节作用
Cell Immunol. 1979 Jun;45(1):199-206. doi: 10.1016/0008-8749(79)90377-0.
8
Stimulatory effect of N-acetyl Muramyl dipeptide in vivo: proliferation of bone marrow progenitor cells in mice.N-乙酰胞壁酰二肽在体内的刺激作用：小鼠骨髓祖细胞的增殖
Infect Immun. 1982 Aug;37(2):452-62. doi: 10.1128/iai.37.2.452-462.1982.
9
Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramylpeptides and bacterial lipopolysaccharides with bovine serum albumin.通过口服给予带有牛血清白蛋白的胞壁酰肽和亲脂性衍生物及细菌脂多糖增强小鼠血清抗体产生
Methods Find Exp Clin Pharmacol. 1986 Jan;8(1):19-26.
10
Marked enhancement of macrophage activation induced by synthetic muramyl dipeptide (MDP) conjugate using monoclonal anti-MDP antibodies.使用单克隆抗Muramyl二肽（MDP）抗体对合成Muramyl二肽（MDP）偶联物诱导的巨噬细胞活化有显著增强作用。
Cell Immunol. 1984 Jul;86(2):269-77. doi: 10.1016/0008-8749(84)90381-2.

引用本文的文献

1
Adjuvants et stimulants de l'immunité: propriétés immunorégulatrices du muramyl-dipeptide, des corynébactéries anaérobies et du diéthyldithiocarbamate de sodium.免疫佐剂与免疫刺激剂：胞壁酰二肽、厌氧棒状杆菌及二乙基二硫代氨基甲酸钠的免疫调节特性
Can Vet J. 1988 Jan;29(1):51-8.
2
The experimental and clinical use of immune-modulating drugs in the prophylaxis and treatment of infections.免疫调节药物在感染预防和治疗中的实验及临床应用。
Infection. 1984 Mar-Apr;12(2):157-66. doi: 10.1007/BF01641705.
3
New approaches for control of infections using synthetic or semi-synthetic constructs containing MDP.使用含有胞壁酰二肽的合成或半合成构建体控制感染的新方法。
Springer Semin Immunopathol. 1985;8(4):401-12. doi: 10.1007/BF01857393.
4
Immunoresponses to Neisseria meningitidis epitopes: in vivo analysis of immunocompetent cells involved in suppression of secondary response to phosphorylcholine.针对脑膜炎奈瑟菌表位的免疫反应：对参与抑制针对磷酸胆碱二次反应的免疫活性细胞的体内分析。
Med Microbiol Immunol. 1987;176(6):289-303. doi: 10.1007/BF00194889.
5
Immunoresponses to Neisseria meningitidis epitopes: suppression of secondary response to phosphorylcholine is carrier specific.对脑膜炎奈瑟菌表位的免疫反应：对磷酰胆碱的二次反应抑制具有载体特异性。
Infect Immun. 1986 Jan;51(1):224-32. doi: 10.1128/iai.51.1.224-232.1986.
6
The experimental and clinical use of immune-modulating drugs in the prophylaxis and treatment of infections.免疫调节药物在感染预防和治疗中的实验及临床应用。
Infection. 1985;13 Suppl 2:S241-50. doi: 10.1007/BF01644438.

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Role of antigen-presenting cells in the development and persistence of contact hypersensitivity.抗原呈递细胞在接触性超敏反应的发生和持续中的作用。
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Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.体外暴露于胞壁酰二肽或脂多糖的巨噬细胞中超氧阴离子生成增加。
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Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.一种无致热原性的新型合成胞壁酰肽佐剂的生物活性。
Infect Immun. 1982 Feb;35(2):417-24. doi: 10.1128/iai.35.2.417-424.1982.
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Macrophage-stimulating effect of a synthetic muramyl dipeptide and its adjuvant-active and -inactive analogs for the production of T-cell activating monokines.一种合成的胞壁酰二肽及其佐剂活性和非活性类似物对T细胞激活单核因子产生的巨噬细胞刺激作用。
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T-cell growth factor.T细胞生长因子。
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Feedback suppression of the immune response in vivo. II. Involvement of prostaglandins in the generation of suppressor-inducer B lymphocytes.
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Demonstration of muramyl dipeptide (MDP)-induced T suppressor cells responsible for MDP immunosuppressive activity.证明负责胞壁酰二肽（MDP）免疫抑制活性的MDP诱导的T抑制细胞。
Eur J Immunol. 1982 Mar;12(3):249-52. doi: 10.1002/eji.1830120316.
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Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte activating factor.具有佐剂活性的分枝杆菌成分和胞壁酰二肽可诱导淋巴细胞激活因子。
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The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.巨噬细胞在抗原刺激中的调节作用。第二部分：淋巴细胞与巨噬细胞之间的共生关系。
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胞壁酰二肽增强抗原特异性抑制作用。

Enhancement of antigen-specific suppression by muramyl dipeptide.

作者信息

Ferguson T A, Krieger N J, Pesce A, Michael J G

出版信息

Infect Immun. 1983 Feb;39(2):800-6. doi: 10.1128/iai.39.2.800-806.1983.

DOI:10.1128/iai.39.2.800-806.1983
PMID:6187686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC348020/
Abstract

The effect of the synthetic adjuvant MDP (N-acetyl-muramyl-L-alanyl-D-isoglu-tamine) on the generation of antigen-specific suppression was investigated. Suppression of the anti-bovine serum albumin response, which was achieved by intravenous administration of a peptic fragment of the antigen, was greatly enhanced by simultaneous administration of MDP. Induction of suppression by a combination of bovine serum albumin fragments and MDP was found to be antigen specific and appeared to occur via the generation of antigen-specific suppressor T cells.

摘要

研究了合成佐剂MDP（N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺）对抗原特异性抑制作用的产生。通过静脉注射抗原的胃蛋白酶片段实现的抗牛血清白蛋白反应的抑制，因同时给予MDP而大大增强。发现牛血清白蛋白片段与MDP联合诱导的抑制是抗原特异性的，并且似乎是通过产生抗原特异性抑制性T细胞而发生的。